The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis - Architecture et Fonction des Macromolécules Biologiques Accéder directement au contenu
Article Dans Une Revue Structure Année : 2022

The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis

Résumé

In this issue of Structure, Armstrong and colleagues probe the structure of human fucosidase FucA1. Their work resolves an ongoing debate around the enzyme’s catalytic mechanism and provides a valid structural template to guide the design of drugs alleviating the rare, yet severe, lysosomal storage disease fucosidosis.
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Dates et versions

hal-03806314 , version 1 (07-10-2022)

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Sarah Barelier, Gerlind Sulzenbacher. The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis. Structure, 2022, 30 (10), pp.1369-1371. ⟨10.1016/j.str.2022.09.002⟩. ⟨hal-03806314⟩
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