Effect of the PPAR gamma C161T Gene Variant on Serum Lipids in Ischemic Stroke Patients with and Without Type 2 Diabetes Mellitus - Biological Adaptation and Ageing Accéder directement au contenu
Article Dans Une Revue Journal of Molecular Neuroscience Année : 2014

Effect of the PPAR gamma C161T Gene Variant on Serum Lipids in Ischemic Stroke Patients with and Without Type 2 Diabetes Mellitus

Khouloud Chehaibi
  • Fonction : Auteur
Samir Nouira
  • Fonction : Auteur
Kacem Mahdouani
  • Fonction : Auteur
Sonia Hamdi
Mohamed Naceur Slimane
  • Fonction : Auteur

Résumé

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated transcription factor involved in the regulation of lipid metabolism, diabetes, obesity, atherogenesis and inflammation. PPAR gamma genetic variation has been associated with metabolic and cardiovascular diseases. The aim of this study was to explore, for the first time, the relationship between PPAR gamma C161T polymorphism and the risk of ischemic stroke (IS) among patients with type 2 diabetes mellitus (T2DM). A total of 196 patients with IS (117 diabetics and 79 nondiabetics) and 192 controls were recruited to enroll in this study. PPAR gamma C161T genotyping was performed by PCR-RFLP technique. The 161T allele as compared with C allele was found to be higher in controls than in IS patients (with or without T2DM). After adjusting for multiple risk factors, the T allele carriers had significantly reduced IS risk (OR = 0.575, 95 % CI 0.348-0.951, p = 0.030) compared to the CC homozygotes which increased significantly the risk in IS patients with T2DM (OR = 1.85, 95 % CI 1.23-2.62). Moreover, the triglycerides (TG) and ApoB levels in CC homozygote carriers were significantly higher than those in T allele carriers. These results indicate that the C161T of PPAR gamma may reduce the risk of IS by modulation of adipose metabolism especially TG and ApoB in IS patients with T2DM.
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Dates et versions

hal-01543972 , version 1 (21-06-2017)

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Citer

Khouloud Chehaibi, Samir Nouira, Kacem Mahdouani, Sonia Hamdi, Mustapha Rouis, et al.. Effect of the PPAR gamma C161T Gene Variant on Serum Lipids in Ischemic Stroke Patients with and Without Type 2 Diabetes Mellitus. Journal of Molecular Neuroscience, 2014, 54 (4), pp.730-738. ⟨10.1007/s12031-014-0326-3⟩. ⟨hal-01543972⟩
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