Protective effect of female gender-related factors on muscle force-generating capacity and fragility in the dystrophic mdx mouse - Biological Adaptation and Ageing Accéder directement au contenu
Article Dans Une Revue Muscle & Nerve Année : 2013

Protective effect of female gender-related factors on muscle force-generating capacity and fragility in the dystrophic mdx mouse

Christophe Hourde
  • Fonction : Auteur
Pierre Joanne
Philippe Noirez
Onnik Agbulut
Gillian Butler-Browne
Arnaud Ferry

Résumé

Introduction: The dystrophic features in hindlimb skeletal muscles of female mdx mice are unclear. Methods: We analyzed force-generating capacity and force decline after lengthening contraction-induced damage (fragility). Results: Young (6-month-old) female mdx mice displayed reduced force-generating capacity (-18%) and higher fragility (23% force decline) compared with female age-matched wild-type mice. These 2 dystrophic features were less accentuated in young female than in young male mdx mice (-32% and 42% force drop). With advancing age, force-generating capacity decreased and fragility increased in old (20 month) female mdx mice (-21% and 57% force decline), but they were unchanged in old male mdx mice. Moreover, estradiol treatment had no effect in old female mdx mice. Conclusions: Female gender-related factors mitigate dystrophic features in young but not old mdx mice. Further studies are warranted to identify the beneficial gender-related factor in dystrophic muscle. Muscle Nerve, 2013

Dates et versions

hal-01545455 , version 1 (22-06-2017)

Identifiants

Citer

Christophe Hourde, Pierre Joanne, Philippe Noirez, Onnik Agbulut, Gillian Butler-Browne, et al.. Protective effect of female gender-related factors on muscle force-generating capacity and fragility in the dystrophic mdx mouse. Muscle & Nerve, 2013, 48 (1), pp.68-75. ⟨10.1002/mus.23700⟩. ⟨hal-01545455⟩
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