Interleukin-10 Production in Response to Amyloid-beta Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease - Biological Adaptation and Ageing Accéder directement au contenu
Article Dans Une Revue Journal of Alzheimer's Disease Année : 2015

Interleukin-10 Production in Response to Amyloid-beta Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease

Delphine Asselineau
  • Fonction : Auteur
Khadija Benlhassan
  • Fonction : Auteur
Beatrice Arosio
  • Fonction : Auteur
Daniela Mari
  • Fonction : Auteur
Evelyn Ferri
  • Fonction : Auteur
Martina Casati
  • Fonction : Auteur
Cristina Gussago
  • Fonction : Auteur
Enzo Tedone
  • Fonction : Auteur
Giorgio Annoni
  • Fonction : Auteur
Paolo Mazzola
  • Fonction : Auteur
Francois Piette
  • Fonction : Auteur
Joel Belmin
Sylvie Pariel
  • Fonction : Auteur
Anne Bornand
  • Fonction : Auteur
Jean-Louis Beaudeux
  • Fonction : Auteur
Dorothy H. Bray
  • Fonction : Auteur

Résumé

We investigated IL-10 and IL-6 production in amyloid-beta (A beta) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-beta 1 (TGF-beta 1) (-10, -25), interferon-beta (IFN-gamma) (-874), and tumor necrosis factor-alpha (TNF-alpha) (-308) genes were analyzed. IL-10 production after A beta stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners. Association between AA IFN-gamma low-producing genotype and fast progression was demonstrated. Investigations in a larger sample will clarify these findings.

Dates et versions

hal-01545783 , version 1 (23-06-2017)

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Citer

Delphine Asselineau, Khadija Benlhassan, Beatrice Arosio, Daniela Mari, Evelyn Ferri, et al.. Interleukin-10 Production in Response to Amyloid-beta Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease. Journal of Alzheimer's Disease, 2015, 46 (4), pp.837-842. ⟨10.3233/JAD-142832⟩. ⟨hal-01545783⟩
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