Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals - Biological Adaptation and Ageing Accéder directement au contenu
Article Dans Une Revue Journal of Neurochemistry Année : 2019

Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals

Résumé

The caudal part of the striatum, also named the tail of the striatum (TS), defines a fourth striatal domain. Determining whether rewarding, aversive and salient stimuli regulate the activity of striatal spiny projections neurons (SPNs) of the TS is therefore of paramount importance to understand its functions, which remain largely elusive. Taking advantage of genetically encoded biosensors (A-kinase activity reporter 3) to record protein kinase A signals and by analyzing the distribution of dopamine D1R- and D2R-SPNs in the TS, we characterized three subterritories: a D2R/A2aR-lacking, a D1R/D2R-intermingled and a D1R/D2R-SPNs-enriched area (corresponding to the amygdalostriatal transition). In addition, we provide evidence that the distribution of D1R- and D2R-SPNs in the TS is evolutionarily conserved (mouse, rat, gerbil). The in vivo analysis of extracellular signal-regulated kinase (ERK) phosphorylation in these TS subterritories in response to distinct appetitive, aversive and pharmacological stimuli revealed that SPNs of the TS are not recruited by stimuli triggering innate aversive responses, fasting, satiety, or palatable signals whereas a reduction in ERK phosphorylation occurred following learned avoidance. In contrast, D1R-SPNs of the intermingled and D2R/A2aR-lacking areas were strongly activated by both D1R agonists and psychostimulant drugs (d-amphetamine, cocaine, 3,4-methyl enedioxy methamphetamine, or methylphenidate), but not by hallucinogens. Finally, a similar pattern of ERK activation was observed by blocking selectively dopamine reuptake. Together, our results reveal that the caudal TS might participate in the processing of specific reward signals and discrete aversive stimuli. Cover Image for this issue: doi: 10.1111/jnc.14526. Open Science: This manuscript was awarded with the Open Materials Badge For more information see: https://cos.io/our-services/open-science-badges/.
Fichier principal
Vignette du fichier
533299.full.pdf (4.12 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02353294 , version 1 (15-11-2022)

Identifiants

Citer

Giuseppe Gangarossa, Laia Castell, Liliana Castro, Pauline Tarot, Frederic Veyrunes, et al.. Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals. Journal of Neurochemistry, 2019, 151 (2), pp.204-226. ⟨10.1111/jnc.14804⟩. ⟨hal-02353294⟩
77 Consultations
14 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More