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Article Dans Une Revue AJP - Gastrointestinal and Liver Physiology Année : 2007

Delayed liver regeneration in mice lacking liver serum response factor

SRF IS A NEW PLAYER INVOLVED IN LIVER REGENERATION

M. Ujue Latasa
  • Fonction : Auteur
Dominique Couton
  • Fonction : Auteur
Claude L. Charvet
David Tuil
  • Fonction : Auteur
Claudia Mitchell
  • Fonction : Auteur
Hélène Gilgenkrantz
  • Fonction : Auteur correspondant
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Résumé

Various immediate early genes (IEGs) upregulated during the early process of liver regeneration are transcriptional targets of the serum response factor (SRF). We show here that the expression of SRF is rapidly induced in rodent liver after partial hepatectomy. Because the inactivation of the SRF gene in mice is embryonic lethal, the in vivo role of SRF in liver regeneration after partial hepatectomy was analyzed in mutant mice conditionally deleted for SRF in the liver. We demonstrate that SRF is not an essential factor for liver ontogenesis. However, adult mutant mice show impaired liver regeneration after partial hepatectomy, associated with a blunted upregulation of various SRF target IEGs. In conclusion, our work suggests that SRF is an early response transcription factor that may contribute to the initial phases of liver regeneration through its activation of IEGs.

Dates et versions

hal-03120722 , version 1 (25-01-2021)

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Citer

M. Ujue Latasa, Dominique Couton, Claude L. Charvet, Aurélie Lafanechère, Jacques-Emmanuel Guidotti, et al.. Delayed liver regeneration in mice lacking liver serum response factor. AJP - Gastrointestinal and Liver Physiology, 2007, 292 (4), pp.G996-G1001. ⟨10.1152/ajpgi.00493.2006⟩. ⟨hal-03120722⟩
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