Dopamine signaling in the striatum - Unité de Biologie Fonctionnelle et Adaptative Accéder directement au contenu
Chapitre D'ouvrage Année : 2019

Dopamine signaling in the striatum

Résumé

The striatum integrates dopamine-mediated reward signals to generate appropriate behavior in response to glutamate-mediated sensory cues. Such associative learning relies on enduring neural plasticity in striatal GABAergic spiny projection neurons which, when altered, can lead to the development of a wide variety of pathological states. Considerable progress has been made in our understanding of the intracellular signaling mechanisms in dopamine-related behaviors and pathologies. Through the prism of the regulation of histone H3 and ribosomal protein S6 phosphorylation, we review how dopamine-mediated signaling events regulate gene transcription and mRNA translation. Particularly, we focus on the intracellular cascades controlling these phosphorylations downstream of the modulation of dopamine receptors by psychostimulants, antipsychotics and l-DOPA. Finally, we highlight the importance to precisely determine in which neuronal populations these signaling events occur in order to understand how they participate in remodeling neural circuits and altering dopamine-related behaviors.

Dates et versions

hal-02399531 , version 1 (09-12-2019)

Identifiants

Citer

Emmanuel Valjent, Anne Biever, Giuseppe Gangarossa, Emma Puighermanal. Dopamine signaling in the striatum. Advances in protein chemistry and structural biology, 116, pp.375-396, 2019, ⟨10.1016/bs.apcsb.2019.01.004⟩. ⟨hal-02399531⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More