Old Paradoxes and New Opportunities for Appetite Control in Obesity - Unité de Biologie Fonctionnelle et Adaptative Accéder directement au contenu
Article Dans Une Revue Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism Année : 2021

Old Paradoxes and New Opportunities for Appetite Control in Obesity

Résumé

Human obesity is accompanied by alterations in the blood concentrations of multiple circulating appetite regulators. Paradoxically, most of the appetite-inhibitory hormones are elevated in nonsyndromic obesity, while most of the appetite stimulatory hormones are reduced, perhaps reflecting vain attempts of regulation by inefficient feedback circuitries. In this context, it is important to understand which appetite regulators exhibit a convergent rather than paradoxical behavior and hence are likely to contribute to the maintenance of the obese state. Pharmacological interventions in obesity should preferentially consist of the supplementation of deficient appetite inhibitors or the neutralization of excessive appetite stimulators. Here, we critically analyze the current literature on appetite-regulatory peptide hormones. We propose a short-list of appetite modulators that may constitute the best candidates for therapeutic interventions.
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hal-03237208 , version 1 (24-04-2023)

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Paternité - Pas d'utilisation commerciale

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Léa Montégut, Carlos Lopez-Otin, Christophe Magnan, Guido Kroemer. Old Paradoxes and New Opportunities for Appetite Control in Obesity. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , 2021, 32 (5), pp.264-294. ⟨10.1016/j.tem.2021.02.005⟩. ⟨hal-03237208⟩
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