Article Dans Une Revue Cortex Année : 2024

Complex memories induced by intracranial electrical brain stimulation are related to complex networks

Jonathan Curot
Vincent Dornier
  • Fonction : Auteur
Luc Valton
  • Fonction : Auteur
Marie Denuelle
  • Fonction : Auteur
Alexis Robin
Florence Rulquin
  • Fonction : Auteur
Jean-Christophe Sol
  • Fonction : Auteur
Amaury de Barros
  • Fonction : Auteur
Agnès Trébuchon
  • Fonction : Auteur
Christian Bénar
  • Fonction : Auteur
Fabrice Bartolomei
  • Fonction : Auteur
Emmanuel J Barbeau
  • Fonction : Auteur

Résumé

The precise and fleeting moment of rich recollection triggered by an environmental cue is difficult to reproduce in the lab. However, epilepsy patients can experience sudden reminiscences after intracranial electrical brain stimulation (EBS). In these cases, the transient brain state related to the activation of the engram and its conscious perception can be recorded using intracerebral EEG (iEEG).

We collected various EBS-induced reminiscences for iEEG analysis, classifying them as follows: no or weak details (familiarity); moderate details and context (semantic and personal semantic memories); high details and context (episodic). Nine brain areas were selected within the temporal lobes (including the hippocampus and temporal neocortex, ipsi-and contralateral) and the insula, defining a network (each area as a node). Functional connectivity was measured by estimating pair-wise non-linear correlations between signals recorded from these brain regions during different memory events. Seventeen reminiscences in six patients (2 episodic, 10 personal semantic, 2 semantic memories, 5 familiar objects, 1 d ej a-rêv e) were compared to 18 control experiential phenomena (unrelated to reminiscence), 18 negative EBS (which failed to elicit memories or other phenomena) in the same locations, and pre-EBS baseline activity.

The global functional connectivity in the network was higher following EBS-induced reminiscences than during baseline activity, control phenomena, or negative EBS.

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hal-04887090 , version 1 (14-01-2025)

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Jonathan Curot, Vincent Dornier, Luc Valton, Marie Denuelle, Alexis Robin, et al.. Complex memories induced by intracranial electrical brain stimulation are related to complex networks. Cortex, 2024, ⟨10.1016/j.cortex.2024.11.015⟩. ⟨hal-04887090⟩
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