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Article Dans Une Revue Current Opinion in Chemical Biology Année : 2023

Tuning specificity and topology of lectins through synthetic biology

Résumé

Lectins are non-immunoglobulin and non-catalytic glycan binding proteins that are able to decipher the structure and function of complex glycans. They are widely used as biomarkers for following alteration of glycosylation state in many diseases and have application in therapeutics. Controlling and extending lectin specificity and topology is the key for obtaining better tools. Furthermore, lectins and other glycan binding proteins can be combined with additional domains, providing novel functionalities. We provide a view on the current strategy with a focus on synthetic biology approaches yielding to novel specificity, but other novel architectures with novel application in biotechnology or therapy.

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Chimie
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Origine : Publication financée par une institution

Dates et versions

hal-03988195 , version 1 (14-02-2023)

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Simona Notova, Anne Imberty. Tuning specificity and topology of lectins through synthetic biology. Current Opinion in Chemical Biology, 2023, 73, pp.02275. ⟨10.1016/j.cbpa.2023.102275⟩. ⟨hal-03988195⟩
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