Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study
David Luque-Paz
(1, 2)
,
Pierre Tattevin
(1, 2, 3)
,
Paul Loubet
(4, 5, 6)
,
François Bénézit
(1)
,
Vincent Thibault
(1)
,
Fabrice Lainé
(3, 1, 6)
,
Philippe Vanhems
(7, 8)
,
Selilah Amour
(7)
,
Bruno Lina
(7)
,
Xavier Duval
(6, 9)
,
Anne-Sophie L’honneur
(10)
,
Nadhira Fidouh
(11)
,
Christine Vallejo
(12)
,
Sophie Alain
(13)
,
Florence Galtier
(14)
,
Vincent Foulongne
(15)
,
Gisèle Lagathu
(1)
,
Nezha Lenzi
(6)
,
Zineb Lesieur
(6)
,
Odile Launay
(16)
,
Stéphane Jouneau
(1, 17)
,
P. Loulergue
,
S. Momcilovic
,
J. Mira
,
N. Marin
,
J. Charpentier
,
A. Regent
,
R. Kanaan
,
F. Dumas
,
B. Doumenc
,
M. Lachatre
,
T. Szwebel
,
J. Kansao
,
Y. Costa
,
J. Alexandra
,
H. Becheur
,
K. Belghalem
,
J. Bernard
,
A. Bleibtreu
,
M. Boisseau
,
R. Bories
,
O. Brugiere
,
F. Brunet
,
C. Burdet
,
E. Casalino
,
M. Caseris
,
C. Chansiaux
,
M. Chauchard
,
P. Chavance
,
C. Choquet
,
A. Cloppet-Fontaine
,
L. Colosi
,
B. Couset
,
B. Crestani
,
F. Crocket
,
A. Debit
,
K Delanoe
,
V. Descamps
,
P. Dieude
,
A. Dossier
,
N. Douron
,
E. Dupeyrat
,
N. Emeyrat
,
C. Fernet
,
T. Goulenok
,
S. Harent
,
R. Jouenne
,
A. Justet
,
A. Leleu
,
I. Lerat
,
M. Lilamand
,
H. Mal
,
A. Marceau
,
A.-C. Metivier
,
K. Oplelatora
,
T. Papo
,
A.-L. Pelletier
,
L. Pereira
,
P. Pradere
,
R Prommier
,
P. Ralainnazava
,
M. Ranaivoision
,
A. Raynaud-Simon
,
C. Rioux
,
K. Sacre
,
V. Verry
,
V. Vuong
,
Y. Yazdapanah
,
N. Houhou
,
P. Géraud
,
V. Driss
,
V. Maugueret
,
L. Crantelle
,
C. Agostini
,
M. Ray
,
F. Letois
,
T. Mura
,
C. Serrand
,
S. Noslier
,
A. Giordano
,
H. Chevassus
,
E. Nyiramigisha
,
C. Merle
,
A. Bourdin
(18, 19)
,
A. Konaté
,
X. Capdevilla
,
G. Du Cailar
,
A. Terminet
,
H. Blain
,
M. Leglise
,
A. Le Quellec
,
P. Corne
,
L. Landreau
,
K. Klouche
(18, 19)
,
A. Bourgeois
,
M. Sebbane
,
G. Mourad
,
H. Leray
,
D. Postil
,
S. Alcolea
,
E. Couve-Deacon
,
S. Rogez
,
L. Argaud
,
M. Cour
,
R. Hernu
,
M. Simon
,
T. Baudry
,
K. Tazarourte
,
C. Bui-Xuan
,
J. Fattoum
,
M. Valette
,
S. Rochas
,
S. Cochennec
,
E. Thébault
,
M. Revest
,
M. Sébillotte
,
A. Le Bot
,
M. Baldeyrou
,
S. Patrat-Delon
,
M. Cailleaux
,
C. Pronier
1
CHU Pontchaillou [Rennes]
2 BRM - ARN régulateurs bactériens et médecine
3 CIC - Centre d'Investigation Clinique [Rennes]
4 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
5 VBIC - Virulence Bactérienne et Infections Chroniques
6 F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
7 HCL - Hospices Civils de Lyon
8 CIRI - Centre International de Recherche en Infectiologie
9 CIC - CHU Bichat
10 Hôpital Cochin [AP-HP]
11 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
12 CIC1435 - Centre d'Investigation Clinique de Limoges
13 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
14 CIC Montpellier
15 CHU Montpellier
16 CIC 1417 - CIC Cochin Pasteur
17 Irset - Institut de recherche en santé, environnement et travail
18 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
19 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 BRM - ARN régulateurs bactériens et médecine
3 CIC - Centre d'Investigation Clinique [Rennes]
4 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
5 VBIC - Virulence Bactérienne et Infections Chroniques
6 F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC)
7 HCL - Hospices Civils de Lyon
8 CIRI - Centre International de Recherche en Infectiologie
9 CIC - CHU Bichat
10 Hôpital Cochin [AP-HP]
11 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
12 CIC1435 - Centre d'Investigation Clinique de Limoges
13 RESINFIT - Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques
14 CIC Montpellier
15 CHU Montpellier
16 CIC 1417 - CIC Cochin Pasteur
17 Irset - Institut de recherche en santé, environnement et travail
18 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
19 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
David Luque-Paz
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- PersonId : 1119497
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Pierre Tattevin
- Function : Author
- PersonId : 756765
- ORCID : 0000-0003-3617-5411
- IdRef : 057598207
Paul Loubet
- Function : Author
- PersonId : 773560
- ORCID : 0000-0002-1218-9432
- IdRef : 192837036
Vincent Thibault
- Function : Author
- PersonId : 177779
- IdHAL : vincent-thibault
- ORCID : 0000-0001-6517-2901
- IdRef : 145706192
Philippe Vanhems
- Function : Author
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- IdRef : 061621196
Bruno Lina
- Function : Author
- PersonId : 761136
- ORCID : 0000-0002-8959-2123
- IdRef : 075685132
Vincent Foulongne
- Function : Author
- PersonId : 759534
- ORCID : 0000-0003-3741-754X
- IdRef : 059843144
Stéphane Jouneau
- Function : Author
- PersonId : 760799
- ORCID : 0000-0002-1949-3461
- IdRef : 124283659
P. Loulergue
- Function : Author
S. Momcilovic
- Function : Author
J. Mira
- Function : Author
N. Marin
- Function : Author
J. Charpentier
- Function : Author
A. Regent
- Function : Author
R. Kanaan
- Function : Author
F. Dumas
- Function : Author
- PersonId : 759487
- ORCID : 0000-0003-2144-9504
B. Doumenc
- Function : Author
M. Lachatre
- Function : Author
T. Szwebel
- Function : Author
J. Kansao
- Function : Author
Y. Costa
- Function : Author
J. Alexandra
- Function : Author
H. Becheur
- Function : Author
K. Belghalem
- Function : Author
J. Bernard
- Function : Author
A. Bleibtreu
- Function : Author
- PersonId : 758344
- ORCID : 0000-0001-5145-4174
- IdRef : 184044316
M. Boisseau
- Function : Author
R. Bories
- Function : Author
O. Brugiere
- Function : Author
F. Brunet
- Function : Author
C. Burdet
- Function : Author
E. Casalino
- Function : Author
M. Caseris
- Function : Author
C. Chansiaux
- Function : Author
M. Chauchard
- Function : Author
P. Chavance
- Function : Author
C. Choquet
- Function : Author
A. Cloppet-Fontaine
- Function : Author
L. Colosi
- Function : Author
B. Couset
- Function : Author
B. Crestani
- Function : Author
F. Crocket
- Function : Author
A. Debit
- Function : Author
K Delanoe
- Function : Author
V. Descamps
- Function : Author
P. Dieude
- Function : Author
A. Dossier
- Function : Author
N. Douron
- Function : Author
E. Dupeyrat
- Function : Author
N. Emeyrat
- Function : Author
C. Fernet
- Function : Author
T. Goulenok
- Function : Author
S. Harent
- Function : Author
R. Jouenne
- Function : Author
A. Justet
- Function : Author
A. Leleu
- Function : Author
I. Lerat
- Function : Author
M. Lilamand
- Function : Author
H. Mal
- Function : Author
A. Marceau
- Function : Author
A.-C. Metivier
- Function : Author
K. Oplelatora
- Function : Author
T. Papo
- Function : Author
A.-L. Pelletier
- Function : Author
L. Pereira
- Function : Author
P. Pradere
- Function : Author
R Prommier
- Function : Author
P. Ralainnazava
- Function : Author
M. Ranaivoision
- Function : Author
A. Raynaud-Simon
- Function : Author
C. Rioux
- Function : Author
K. Sacre
- Function : Author
V. Verry
- Function : Author
V. Vuong
- Function : Author
Y. Yazdapanah
- Function : Author
N. Houhou
- Function : Author
P. Géraud
- Function : Author
V. Driss
- Function : Author
V. Maugueret
- Function : Author
L. Crantelle
- Function : Author
C. Agostini
- Function : Author
M. Ray
- Function : Author
F. Letois
- Function : Author
T. Mura
- Function : Author
C. Serrand
- Function : Author
S. Noslier
- Function : Author
A. Giordano
- Function : Author
H. Chevassus
- Function : Author
E. Nyiramigisha
- Function : Author
C. Merle
- Function : Author
A. Bourdin
- Function : Author
- PersonId : 975030
- ORCID : 0000-0002-4645-5209
- IdRef : 070160228
A. Konaté
- Function : Author
X. Capdevilla
- Function : Author
G. Du Cailar
- Function : Author
A. Terminet
- Function : Author
H. Blain
- Function : Author
M. Leglise
- Function : Author
A. Le Quellec
- Function : Author
P. Corne
- Function : Author
L. Landreau
- Function : Author
K. Klouche
- Function : Author
- PersonId : 930999
- ORCID : 0000-0003-1633-7700
A. Bourgeois
- Function : Author
M. Sebbane
- Function : Author
G. Mourad
- Function : Author
H. Leray
- Function : Author
D. Postil
- Function : Author
S. Alcolea
- Function : Author
E. Couve-Deacon
- Function : Author
S. Rogez
- Function : Author
L. Argaud
- Function : Author
M. Cour
- Function : Author
R. Hernu
- Function : Author
M. Simon
- Function : Author
- PersonId : 774633
- ORCID : 0000-0003-3655-6329
- IdRef : 097642843
T. Baudry
- Function : Author
K. Tazarourte
- Function : Author
C. Bui-Xuan
- Function : Author
J. Fattoum
- Function : Author
M. Valette
- Function : Author
S. Rochas
- Function : Author
S. Cochennec
- Function : Author
E. Thébault
- Function : Author
M. Revest
- Function : Author
M. Sébillotte
- Function : Author
A. Le Bot
- Function : Author
M. Baldeyrou
- Function : Author
S. Patrat-Delon
- Function : Author
M. Cailleaux
- Function : Author
C. Pronier
- Function : Author
Abstract
Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.
Origin : Files produced by the author(s)