Relapse factors for ileal neuroendocrine tumours after curative surgery: a retrospective French multicentre study. - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue Digestive and Liver Disease Année : 2011

Relapse factors for ileal neuroendocrine tumours after curative surgery: a retrospective French multicentre study.

Résumé

AIM: To evaluate the characteristics of postoperative relapse, predictive factors and time to relapse after curative surgery for well-differentiated neuroendocrine tumours of the ileum, without hepatic or other distant metastases. METHODS: Clinical data of patients entered into the Groupe d'étude des Tumeurs Endocrines database were collected and analysed retrospectively to identify factors predictive of relapse. RESULTS: Among 100 patients followed for a median of 56.5 (range 1-290) months, 42 relapsed after a median follow-up of 57.5 (range 6-176) months, with liver lesions in 27 (64.3%). Median disease-free survival (Kaplan-Meier) was 88 months (95% confidence interval 72-115). Disease-free survival was shorter for emergency surgery patients (p<0.01), patients with distant mesenteric lymph-node metastases (p<0.01), with fortuitous diagnosis (p=0.02), with tumour diameter >20mm (p=0.02), and those with multiple tumours (p=0.07). Multivariate analysis retained emergency surgery (odds-ratio 4.04 [95% confidence interval 2.01-8.11]), distant mesenteric lymph-node metastases (odds-ratio 2.53 [95% confidence interval 1.22-5.25]), and multiple tumours (odds-ratio 2.14 [95% confidence interval 1.01-4.50]), as being significantly associated with relapse. CONCLUSION: Patients who underwent emergency surgery, with distant mesenteric lymph-node metastases or with multiple ileal tumours relapsed earlier. Closer monitoring for the patients with these risk factors may be required.

Domaines

Cancer

Dates et versions

hal-00850119 , version 1 (03-08-2013)

Identifiants

Citer

Catherine Le Roux, Catherine Lombard-Bohas, Christelle Delmas, Sophie Dominguez-Tinajero, Philippe Ruszniewski, et al.. Relapse factors for ileal neuroendocrine tumours after curative surgery: a retrospective French multicentre study.. Digestive and Liver Disease, 2011, 43 (10), pp.828-33. ⟨10.1016/j.dld.2011.04.021⟩. ⟨hal-00850119⟩
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