Totally implantable central venous access port infections in patients with digestive cancer: incidence and risk factors. - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue American Journal of Infection Control Année : 2012

Totally implantable central venous access port infections in patients with digestive cancer: incidence and risk factors.

Résumé

BACKGROUND: Central venous access port-related bloodstream infection (CVAP-BSI) is associated with morbidity and mortality in patients with cancer. This study examined the incidence rates and risk factors for CVAP-BSI in adult patients with digestive cancer. METHODS: This prospective observational cohort study was performed from 2007 to 2011 in 2 oncology units of a university hospital. Incidence rate was expressed as number of CVAP-BSI per 1,000 catheter-days. A Cox regression model was used to identify risk factors for CVAP-BSI. RESULTS: A total of 315 patients were included. CVAP-BSI occurred in 41 patients (13.0%). The overall incidence rate was 0.76/1,000 catheter-days. The rate was higher in patients with esophageal cancer (1.28. P = .05) and pancreatic cancer (1.24; P = .007). Risk factors independently associated with CVAP-BSI were World Health Organization performance status between 2 and 4, catheter utilization-days in the previous month, pancreatic cancer, and parenteral nutrition. Coagulase-negative Staphylococci and enterobacteria were the main microorganisms isolated. CONCLUSIONS: In adult patients with digestive cancer, pancreatic cancer, cumulative catheter utilization-days, World Health Organization performance status, and parenteral nutrition were identified as independent risk factors for CVAP-BSI. Patients with any of these risk factors could be candidates for preventive strategies.

Dates et versions

hal-00965810 , version 1 (25-03-2014)

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Citer

Abdoulaye Touré, Philippe Vanhems, Catherine Lombard-Bohas, Philippe Cassier, Denis Péré-Vergé, et al.. Totally implantable central venous access port infections in patients with digestive cancer: incidence and risk factors.. American Journal of Infection Control, 2012, 40 (10), pp.935-9. ⟨10.1016/j.ajic.2012.01.024⟩. ⟨hal-00965810⟩
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