La classification histo-moléculaire des cancers épithéliaux ovariens en 2 types est-elle pertinente ? - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue Bulletin du Cancer Année : 2016

Dualistic classification of epithelial ovarian cancer: Is it clinically relevant?

La classification histo-moléculaire des cancers épithéliaux ovariens en 2 types est-elle pertinente ?

Résumé

Malignant epithelial tumors (carcinomas) are the most common ovarian cancers and the most lethal gynecological malignancies. Based on their heterogeneous morphology, a dualistic model of carcinogenesis was proposed in 2004. Type I carcinomas, composed of low grade serous, endometrioid, mucinous, clear cell carcinomas and malignant Brenner tumors, were distinct from type II carcinomas (high grade serous, undifferentiated carcinomas and carcinosarcomas). However, clinical studies failed to demonstrate the prognostic value of such a classification. The main reproach to this dualistic model was that it lumped together in type I tumors, heterogeneous lesions such as clear cell and mucinous carcinomas. Recent advances on molecular genetic alterations and precursor lesions favor the classification of ovarian carcinomas as five distinct diseases. The dualistic model of carcinogenesis in type I and II can finally be applied only to serous ovarian carcinomas (low grade and high grade)

Domaines

Cancer
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Dates et versions

hal-01792627 , version 1 (15-05-2018)

Identifiants

Citer

M. Devouassoux-Shisheboran, C. Genestie, Isabelle Ray-Coquard. La classification histo-moléculaire des cancers épithéliaux ovariens en 2 types est-elle pertinente ?. Bulletin du Cancer, 2016, 103 (3), pp.252-258. ⟨10.1016/j.bulcan.2015.12.005⟩. ⟨hal-01792627⟩
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