Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+regulatory T cells and are associated with poor prognosis in breast cancer patients - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue OncoImmunology Année : 2013

Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+regulatory T cells and are associated with poor prognosis in breast cancer patients

Résumé

The accumulation of plasmacytoid dendritic cells (pDCs) within breast carcinoma lesions is associated with a poor clinical outcome. We demonstrated that the deleterious impact of tumor-associated pDCs (TApDCs) is due to their impaired capacity to produce Type I interferon, which in turn potentiates their ability to sustain the proliferation of immunosuppressive regulatory T cells.
Fichier principal
Vignette du fichier
onci-2-e22338.pdf (275.1 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03045754 , version 1 (08-12-2020)

Identifiants

Citer

Vanja Sisirak, Julien Faget, Nelly Vey, Jean-Yves Blay, Christine Ménétrier-Caux, et al.. Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+regulatory T cells and are associated with poor prognosis in breast cancer patients. OncoImmunology, 2013, 2, ⟨10.4161/onci.22338⟩. ⟨hal-03045754⟩
8 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More