CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue Thyroid Année : 2018

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone

Résumé

Resistance to thyroid hormone due to THRA mutations (RTHα) is a recently discovered genetic disease, displaying important variability in its clinical presentation. The mutations alter the function of TRα1, one of the two nuclear receptors for thyroid hormone.

Dates et versions

hal-03278383 , version 1 (05-07-2021)

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Citer

Suzy S. Markossian, Romain Guyot, Sabine Richard, Marie Teixeira, Nadine Aguilera, et al.. CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone. Thyroid, 2018, 28 (1), pp.139-150. ⟨10.1089/thy.2017.0389⟩. ⟨hal-03278383⟩
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