snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management - Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard) Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Cells Année : 2020

snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management

Résumé

Small nucleolar RNAs (snoRNAs) are non-coding RNAs localized in the nucleolus, where they participate in the cleavage and chemical modification of ribosomal RNAs. Their biogenesis and molecular functions have been extensively studied since their identification in the 1960s. However, their role in cancer has only recently started to emerge. In lung cancer, efforts to profile snoRNA expression have enabled the definition of snoRNA-related signatures, not only in tissues but also in biological fluids, exposing these small RNAs as potential non-invasive biomarkers. Moreover, snoRNAs appear to be essential actors of lung cancer onset and dissemination. They affect diverse cellular functions, from regulation of the cell proliferation/death balance to promotion of cancer cell plasticity. snoRNAs display both oncogenic and tumor suppressive activities that are pivotal in lung cancer tumorigenesis and progression. Altogether, we review how further insight into snoRNAs may improve our understanding of basic lung cancer biology and the development of innovative diagnostic tools and therapies.
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hal-03776373 , version 1 (29-02-2024)

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Nour-El-Houda Mourksi, Chloé Morin, Tanguy Fenouil, Jean-Jacques Diaz, Virginie Marcel. snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management. Cells, 2020, 9 (3), pp.541. ⟨10.3390/cells9030541⟩. ⟨hal-03776373⟩
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