Metabolic reprogramming during the Trypanosoma brucei life cycle - Centre de Résonance Magnétique des Systèmes Biologiques Accéder directement au contenu
Article Dans Une Revue F1000Research Année : 2017

Metabolic reprogramming during the Trypanosoma brucei life cycle

Résumé

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.

Domaines

Parasitologie
Fichier principal
Vignette du fichier
109 Smith-2017.pdf (1.55 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02348134 , version 1 (04-01-2023)

Identifiants

Citer

Terry Smith, Frédéric Bringaud, Derek Nolan, Luisa Figueiredo. Metabolic reprogramming during the Trypanosoma brucei life cycle. F1000Research, 2017, 6, pp.683. ⟨10.12688/f1000research.10342.2⟩. ⟨hal-02348134⟩

Collections

CNRS CRMSB ANR
9 Consultations
19 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More