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Article Dans Une Revue Dalton Transactions Année : 2022

Symmetric CEST-active lanthanide complexes for redox monitoring

Résumé

Two symmetric ligands harbouring two TEMPO radicals and two functionalized acetamide arms (R = OMe (L-1), CF3 (L-2)) were prepared and chelated to lanthanide ions (Eu-III, Yb-III for both L-1 and L-2, Dy-III for L-1). Luminescence measurements on the europium complexes support the coordination of a single water molecule. The TEMPO arms are magnetically interacting in L-1 (and its complexes) but not in L-2. The TEMPO moieties can be reversibly oxidized into an oxoammonium (0.33-0.36 V vs. Fc(+)/Fc) or reduced into a hydroxylamine (ill-defined redox wave, reduction by ascorbate), which are both diamagnetic. The europium complexes [Eu(L-1)](3+) and [Eu(L-2)](3+) in their hydroxylamine form exhibit a temperature dependent CEST effect, which is maximal at 25°C (30%) and 37°C (12%), respectively. The CEST activity is dramatically reduced in the corresponding nitroxide forms due to the paramagnetism of the ligand. The europium complexes show no cytotoxicity against M21 cell lines over long incubation times (72 h) at high concentration (40 μM).
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Origine : Publication financée par une institution

Dates et versions

hal-04030644 , version 1 (15-03-2023)

Identifiants

Citer

Damien Mouchel Dit Leguerrier, Richard Barré, Quentin Ruet, Véronique Frachet, Daniel Imbert, et al.. Symmetric CEST-active lanthanide complexes for redox monitoring. Dalton Transactions, 2022, 51 (48), pp.18400-18408. ⟨10.1039/d2dt02776c⟩. ⟨hal-04030644⟩
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