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Article Dans Une Revue Nature Communications Année : 2023

An interactive murine single-cell atlas of the lung responses to radiation injury

Sophie Heinrich
Sophie Leboucher
Marie Dutreix

Résumé

Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter being a life-threatening condition. The order of cellular and molecular events in the progression towards fibrosis is key to the physiopathogenesis of the disease, yet their coordination in space and time remains largely unexplored. Here, we present an interactive murine single cell atlas of the lung response to irradiation, generated from C57BL6/J female mice. This tool opens the door for exploration of the spatio-temporal dynamics of the mechanisms that lead to radiation-induced pulmonary fibrosis. It depicts with unprecedented detail cell type-specific radiation-induced responses associated with either lung regeneration or the failure thereof. A better understanding of the mechanisms leading to lung fibrosis will help finding new therapeutic options that could improve patients’ quality of life.
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Origine : Publication financée par une institution
licence : CC BY - Paternité

Dates et versions

hal-04092147 , version 1 (09-05-2023)

Licence

Paternité

Identifiants

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Sandra Curras-Alonso, Juliette Soulier, Thomas Defard, Christian Weber, Sophie Heinrich, et al.. An interactive murine single-cell atlas of the lung responses to radiation injury. Nature Communications, 2023, 14 (1), pp.2445. ⟨10.1038/s41467-023-38134-z⟩. ⟨hal-04092147⟩
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