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Article Dans Une Revue Science Année : 2022

Y recombination arrest and degeneration in the absence of sexual dimorphism

Résumé

Current theory proposes that degenerated sex chromosomes—such as the mammalian Y—evolve through three steps: (i) recombination arrest, linking male-beneficial alleles to the Y chromosome; (ii) Y degeneration, resulting from the inefficacy of selection in the absence of recombination; and (iii) dosage compensation, correcting the resulting low expression of X-linked genes in males. We investigate a model of sex chromosome evolution that incorporates the coevolution of cis and trans regulators of gene expression. We show that the early emergence of dosage compensation favors the maintenance of Y-linked inversions by creating sex-antagonistic regulatory effects. This is followed by degeneration of these nonrecombining inversions caused by regulatory divergence between the X and Y chromosomes. In contrast to current theory, the whole process occurs without any selective pressure related to sexual dimorphism.
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Dates et versions

hal-03755019 , version 1 (20-08-2022)

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Thomas Lenormand, Denis Roze. Y recombination arrest and degeneration in the absence of sexual dimorphism. Science, 2022, 375 (6581), pp.663-666. ⟨10.1126/science.abj1813⟩. ⟨hal-03755019⟩
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