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Article Dans Une Revue Angewandte Chemie International Edition Année : 2013

Repair of the (6-4) Photoproduct by DNA Photolyase Requires Two Photons

Résumé

Single-turnover flash experiments showed that the flavoenzyme (6-4) photolyase uses a successive two-photon mechanism to repair the UV-induced T(6-4)T lesion in DNA (see picture). The intermediate (X) formed by the first photoreaction is likely to be the oxetane-bridged dimer T(ox)T. The enzyme could stabilize the normally short-lived T(ox)T, allowing repair to be completed by the second photoreaction.

Dates et versions

hal-00846664 , version 1 (19-07-2013)

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Citer

Junpei Yamamoto, Ryan Martin, Shigenori Iwai, Pascal Plaza, Klaus Brettel. Repair of the (6-4) Photoproduct by DNA Photolyase Requires Two Photons. Angewandte Chemie International Edition, 2013, 52, pp.7432. ⟨10.1002/anie.201301567⟩. ⟨hal-00846664⟩
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