Rab-GDI Complex Dissociation Factor Expressed through Translational Frameshifting in Filamentous Ascomycetes. - I2BC Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2013

Rab-GDI Complex Dissociation Factor Expressed through Translational Frameshifting in Filamentous Ascomycetes.

Résumé

In the model fungus Podospora anserina, the PaYIP3 gene encoding the orthologue of the Saccharomyces cerevisiae YIP3 Rab-GDI complex dissociation factor expresses two polypeptides, one of which, the long form, is produced through a programmed translation frameshift. Inactivation of PaYIP3 results in slightly delayed growth associated with modification in repartition of fruiting body on the thallus, along with reduced ascospore production on wood. Long and short forms of PaYIP3 are expressed in the mycelium, while only the short form appears expressed in the maturing fruiting body (perithecium). The frameshift has been conserved over the evolution of the Pezizomycotina, lasting for over 400 million years, suggesting that it has an important role in the wild.

Dates et versions

hal-00867895 , version 1 (30-09-2013)

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Citer

Fabienne Malagnac, Céline Fabret, Magali Prigent, Jean-Pierre Rousset, Olivier Namy, et al.. Rab-GDI Complex Dissociation Factor Expressed through Translational Frameshifting in Filamentous Ascomycetes.. PLoS ONE, 2013, 8 (9), pp.e73772. ⟨10.1371/journal.pone.0073772⟩. ⟨hal-00867895⟩
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