Revised interpretation of the Hain Lifescience GenoType MTBC to differentiate $Mycobacterium\ canettii$ and members of the $Mycobacterium\ tuberculosis$ Complex - I2BC Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2019

Revised interpretation of the Hain Lifescience GenoType MTBC to differentiate $Mycobacterium\ canettii$ and members of the $Mycobacterium\ tuberculosis$ Complex

Résumé

Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum).

Dates et versions

hal-02173134 , version 1 (04-07-2019)

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Citer

Chloe Loiseau, Daniela Brites, Irmgard Moser, Francesc Coll, Christine Pourcel, et al.. Revised interpretation of the Hain Lifescience GenoType MTBC to differentiate $Mycobacterium\ canettii$ and members of the $Mycobacterium\ tuberculosis$ Complex. Antimicrobial Agents and Chemotherapy, 2019, 63 (6), pp.e00159-19. ⟨10.1128/AAC.00159-19⟩. ⟨hal-02173134⟩
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