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Article Dans Une Revue Organic Letters Année : 2018

Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas

Résumé

Overexpression of the Pseudomonas virulence factor (pvf) biosynthetic operon led to the identification of a family of pyrazine N-oxides (PNOs), including a novel dihydropyrazine N,N'-dioxide (dPNO) metabolite. The nonribosomal peptide synthetase responsible for production of (d)PNOs was characterized, and a biosynthetic pathway for (d)PNOs was proposed. This work highlights the unique chemistry catalyzed by pvf-encoded enzymes and sets the stage for bioactivity studies of the metabolites produced by the virulence pathway.

Dates et versions

hal-02179881 , version 1 (11-07-2019)

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Citer

Ashley M. Kretsch, Gina L. Morgan, Jillian Tyne, Emily Meyers, Isabelle Vallet-Gely, et al.. Discovery of (Dihydro)pyrazine N-Oxides via Genome Mining in Pseudomonas. Organic Letters, 2018, 20 (16), pp.4791--4795. ⟨10.1021/acs.orglett.8b01944⟩. ⟨hal-02179881⟩
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