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Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2023

The C-terminus of stathmin-like proteins governs the stability of their complexes with tubulin

Résumé

Microtubule dynamics is modulated by many cellular factors including stathmin family proteins. Vertebrate stathmins sequester two ab-tubulin heterodimers into a tight complex that cannot be incorporated in microtubules. Stathmins are regulated at the expression level during development and among tissues; they are also regulated by phosphorylation. Here, we study the dissociation kinetics of tubulin:stathmin assemblies in presence of different tubulin-binding proteins and identify a critical role of the Cterminus of the stathmin partner. Destabilizing this C-terminal region may represent an additional regulatory mechanism of the interaction with tubulin of stathmin proteins.
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Dates et versions

hal-04100144 , version 1 (11-10-2023)

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Valérie Campanacci, Benoît Gigant. The C-terminus of stathmin-like proteins governs the stability of their complexes with tubulin. Biochemical and Biophysical Research Communications, 2023, 682, pp.244-249. ⟨10.1016/j.bbrc.2023.10.023⟩. ⟨hal-04100144⟩
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