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The C-terminus of stathmin-like proteins governs the stability of their complexes with tubulin

Abstract

Microtubule dynamics is modulated by many cellular factors including stathmin family proteins. Vertebrate stathmins sequester two ab-tubulin heterodimers into a tight complex that cannot be incorporated in microtubules. Stathmins are regulated at the expression level during development and among tissues; they are also regulated by phosphorylation. Here, we study the dissociation kinetics of tubulin:stathmin assemblies in presence of different tubulin-binding proteins and identify a critical role of the Cterminus of the stathmin partner. Destabilizing this C-terminal region may represent an additional regulatory mechanism of the interaction with tubulin of stathmin proteins.
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Dates and versions

hal-04100144 , version 1 (17-05-2023)

Identifiers

  • HAL Id : hal-04100144 , version 1

Cite

Valérie Campanacci, Benoît Gigant. The C-terminus of stathmin-like proteins governs the stability of their complexes with tubulin. 2023. ⟨hal-04100144⟩
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