Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells
Résumé
Highlights d Lineage tracing demonstrates that artery endothelial cells (ECs) form HSCs in vivo d Stepwise hPSC differentiation into artery ECs and then hematopoietic progenitors d Rapid and efficient generation of >90% pure hematopoietic progenitors in 10 days d hPSC-derived hematopoietic progenitors express core HSC markers HLF and HOXA5-10
Domaines
Sciences du Vivant [q-bio]
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Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF plus HOXA plus hematopoietic from pluripotent stem cells.pdf (8.33 Mo)
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