Transketolase and fructose-1,6-bis-phosphate aldolase, complementary tools for access to new ulosonic acid analogues - Institut de Chimie de Clermont-Ferrand Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2004

Transketolase and fructose-1,6-bis-phosphate aldolase, complementary tools for access to new ulosonic acid analogues

Résumé

A new approach to the synthesis of ulosonic acids KDO and DAH is described. The key step is the C5–C6 bond formation catalysed by fructose-1,6-bisphosphate aldolase (for KDO) or transketolase (for DAH) using substituted acrylonitrile α-hydroxyaldehyde. All asymmetric carbon configurations are determined in an enzymatic step by the means of deshydrogenase or lipase. This strategy, using a non-metabolism pathway, allows access to novel precursors of KDO, DAH and analogues

Domaines

Chimie organique
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Dates et versions

hal-00135919 , version 1 (09-03-2007)

Identifiants

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Dominique Crestia, Colette Demuynck, Jean Bolte. Transketolase and fructose-1,6-bis-phosphate aldolase, complementary tools for access to new ulosonic acid analogues. Tetrahedron, 2004, 60, pp.2417-2425. ⟨10.1016/j.tet.2003.12.069⟩. ⟨hal-00135919⟩
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