Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward Acute Myeloid Leukemia cells. - Institut de Chimie de Clermont-Ferrand Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2015

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward Acute Myeloid Leukemia cells.

Résumé

The synthesis of new indolopyrrolobenzodiazepine derivatives is described. Six compounds were selected for evaluation of cytotoxicity towards acute myeloid leukemia (AML) cells and normal fibroblasts. One compound (29) showed selective AML cell death induction. Its action was only partly overcome by knock-down of p53 or Bcl-2 overexpression, suggesting a strong activation of intrinsic apoptotic pathways.

Domaines

Chimie
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Dates et versions

hal-01227182 , version 1 (10-11-2015)

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Francis Giraud, Marion Bourhis, Edris Ebrahimi, Lars Herfindal, Romy Roy Choudhury, et al.. Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward Acute Myeloid Leukemia cells.. Bioorganic and Medicinal Chemistry, 2015, 23, pp.7313-7323. ⟨10.1016/j.bmc.2015.10.031⟩. ⟨hal-01227182⟩
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