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Article Dans Une Revue PLoS ONE Année : 2010

Cardiac Muscarinic Receptor Overexpression in Sudden Infant Death Syndrome

Résumé

Background: Sudden infant death syndrome (SIDS) remains the leading cause of death among infants less than 1 year of age. Disturbed expression of some neurotransmitters and their receptors has been shown in the central nervous system of SIDS victims but no biological abnormality of the peripheral vago-cardiac system has been demonstrated to date. The present study aimed to seek vago-cardiac abnormalities in SIDS victims. The cardiac level of expression of muscarinic receptors, as well as acetylcholinesterase enzyme activity were investigated. Methodology/Principal Findings: Left ventricular samples and blood samples were obtained from autopsies of SIDS and children deceased from non cardiac causes. Binding experiments performed with [3H]NMS, a selective muscarinic ligand, in cardiac membrane preparations showed that the density of cardiac muscarinic receptors was increased as shown by a more than doubled Bmax value in SIDS (n = 9 SIDS versus 8 controls). On average, the erythrocyte acetylcholinesterase enzyme activity was also significantly increased (n = 9 SIDS versus 11 controls). Conclusions: In the present study, it has been shown for the first time that cardiac muscarinic receptor overexpression is associated with SIDS. The increase of acetylcholinesterase enzyme activity appears as a possible regulatory mechanism
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Dates et versions

hal-03807859 , version 1 (02-03-2023)

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Angelo Livolsi, Nathalie Niederhoffer, Nassim Dali-Youcef, Caroline Rambaud, Catherine Olexa, et al.. Cardiac Muscarinic Receptor Overexpression in Sudden Infant Death Syndrome. PLoS ONE, 2010, 5 (3), pp.e9464. ⟨10.1371/journal.pone.0009464⟩. ⟨hal-03807859⟩
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