Effect of ions on the interactions of glass nanoparticles with monolayer lung surfactant. Applications for the study of inhaled airborne wear particles
Résumé
Every year in France, by the wear of the brake pads of small cars, 9000 tons of airborne particles smaller than 2.5 microns are released in the environement and react with the human body, such as starting to show a few studies on the increase number of lung diseases caused by airborne wear particles. These inhaled particles will deposit along the lung airways were they are retained by lung surfactant (LS), meaning that the structure and function of LS may be greatly affected by these particles. LS is a complex structure constituted by phospholipids (90%) and protein (10% SP-A, SP-B, SP-C, SP-D) with two majors roles: to reduce the surface tension avoiding the pulmonary-alveoli collapse, and to act as a barrier against inhaled particles and pathogens. Its dysfunctions lead to severe pathologies like acute respiratory distress syndrome (ARDS) often fatal. Recent studies showed a high influence of nanoparticles (NPs) on pressure response of DPPC monolayer. In this context our study aims to better understand the interactions mechanism of size controlled spherical glass nanoparticles with complex lipid mixture of LS.
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