Synthesis and Characterization of 89 Zr-Labeled Ultrasmall Nanoparticles - Institut Lumière Matière Accéder directement au contenu
Article Dans Une Revue Molecular Pharmaceutics Année : 2016

Synthesis and Characterization of 89 Zr-Labeled Ultrasmall Nanoparticles

Résumé

The ultrasmall nanoparticle AGuIX is a versatile platform that tolerates a range of chemical diversity for theranostic applications. Our previous work showed that AGuIX clears rapidly from normal tissues, while durably accumulating within the tumor microenvironment. On this basis, AGuIX was used to detect tumor tissue with Gd3+ enhanced MRI and can sensitize tumors to radiation therapy. As we begin the translation of AGuIX, we appreciated that coupling AGuIX to a long-lived radioisotope would help to more completely measure the magnitude and duration of its retention within the tumor microenvironment. Therefore, we developed 89Zr-DFO-AGuIX. AGuIX was coupled to DFO and then to 89Zr in ∼99% radiochemical yield. Stability studies showed that 89Zr-DFO-AGuIX did not dissociate after 72 h. In animals bearing U87MG xenografts, it was detectable at levels above background for 72 h. Lastly, 89Zr-DFO-AGuIX did not accumulate in inflammatory abscesses in vivo, highlighting its specificity for well vascularized tumors.

Dates et versions

hal-01405878 , version 1 (30-11-2016)

Identifiants

Citer

Charles Truillet, Eloise Thomas, François Lux, Loc T Huynh, Olivier Tillement, et al.. Synthesis and Characterization of 89 Zr-Labeled Ultrasmall Nanoparticles. Molecular Pharmaceutics, 2016, 13 (7), pp.2596 - 2601. ⟨10.1021/acs.molpharmaceut.6b00264⟩. ⟨hal-01405878⟩
52 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More