Article Dans Une Revue Journal of Infectious Diseases Année : 2025

Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients

Résumé

Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solidorgan transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence.
Fichier principal
Vignette du fichier
LHOMME.pdf (168.8 Ko) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-04889860 , version 1 (15-01-2025)

Identifiants

Citer

Sébastien Lhomme, Cyril Garrouste, Nassim Kamar, Karine Sandres-Sauné, Florence Abravanel, et al.. Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients. Journal of Infectious Diseases, 2025, 209 (2), pp.300-303. ⟨10.1093/infdis/jit438⟩. ⟨hal-04889860⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More