Development of 2-deoxystreptamine–nucleobase conjugates for the inhibition of oncogenic miRNA production
Résumé
2-deoxystreptamine (2-DOS) conjugates with artificial nucleobases were designed and synthesized to inhibit pre-miR-372 processing into oncogenic miRNA and were discovered to be promising inhibitors when compared to their neomycin counterpart.
Domaines
Chimie
Origine : Fichiers produits par l'(les) auteur(s)