Brain Charts for the Rhesus Macaque Lifespan
S. Alldritt
,
J.S.B. Ramirez
,
R. Vos de Wael
,
R. Bethlehem
,
J. Seidlitz
,
Z. Wang
,
K. Nenning
,
N.B. Esper
,
J. Smallwood
,
A.R. Franco
,
K. Byeon
,
A. Alexander-Bloch
,
D.G. Amaral
,
C. Amiez
,
F. Balezeau
,
M.G. Baxter
,
Guillaume Becker
(1)
,
J. Bennett
,
O. Berkner
,
E.L.A. Blezer
,
A.M. Brambrink
,
Thomas Brochier
(2)
,
B. Butler
,
L.J. Campos
,
Emmanuelle Canet-Soulas
(1)
,
Lucie Chalet
(1)
,
A. Chen
,
J. Cléry
,
C. Constantinidis
,
D.J. Cook
,
Stanislas Dehaene
(3)
,
L. Dorfschmidt
,
C.M. Drzewiecki
,
J.W. Erdman
,
S. Everling
,
A. Falchier
,
L. Fleysher
,
A. Fox
,
W. Freiwald
,
Mathilda Froesel
(4)
,
S. Froudist-Walsh
,
J. Fudge
,
T. Funck
,
Maëva Gacoin
(4)
,
D.J. Gale
,
J. Gallivan
,
Clément M. Garin
(4, 5)
,
T.D. Griffiths
,
Carole Guedj
(6)
,
Fadila Hadj-Bouziane
(6, 7)
,
Suliann Ben Hamed
(4)
,
N. Harel
,
R. Hartig
,
Bassem Hiba
(4)
,
B.R. Howell
,
Béchir Jarraya
(3)
,
B. Jung
,
N. Kalin
,
J. Karpf
,
S. Kastner
,
C. Klink
,
Z.A. Kovacs-Balint
,
C. Kroenke
,
M.J. Kuchan
,
S.C. Kwok
,
K.N. Lala
,
D.A. Leopold
,
G. Li
,
P. Lindenfors
,
G. Linn
,
R.B. Mars
,
K. Masiello
,
R.S. Menon
,
A. Messinger
,
M. Meunier
,
K. Mok
,
J.H. Morrison
,
J. Nacef
,
J. Nagy
,
V. Neudecker
,
M. Neuringer
,
M.P. Noonan
,
M. Ortiz-Rios
,
J.F. Perez-Zoghbi
,
C.I. Petkov
,
M. Pinsk
,
C. Poirier
,
E. Procyk
,
R. Rajimehr
,
S.M. Reader
,
D.A. Rudko
,
M.F.S. Rushworth
,
B.E. Russ
,
J. Sallet
,
M.M. Sanchez
,
M.C. Schmid
,
C.M. Schwiedrzik
,
J.A. Scott
,
J. Sein
,
K.K. Sharma
,
A. Shmuel
,
M. Styner
,
E.L. Sullivan
,
A. Thiele
,
O.S. Todorov
,
D. Tsao
,
A. Tusche
,
R. Vlasova
,
Z. Wang
,
L. Wang
,
J. Wang
,
A.R. Weiss
,
C.R.E. Wilson
,
E. Yacoub
,
W. Zarco
,
Y. Zhou
,
J. Zhu
,
D. Margulies
,
D. Fair
,
C. Schroeder
,
M. Milham
,
T. Xu
1
CarMeN -
Cardiovasculaire, métabolisme, diabétologie et nutrition
2 INT - Institut de Neurosciences de la Timone
3 NEUROSPIN - Service NEUROSPIN
4 ISC-MJ - Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229
5 Vanderbilt University [Nashville]
6 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
7 UNIGE - Université de Genève = University of Geneva
2 INT - Institut de Neurosciences de la Timone
3 NEUROSPIN - Service NEUROSPIN
4 ISC-MJ - Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229
5 Vanderbilt University [Nashville]
6 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
7 UNIGE - Université de Genève = University of Geneva
S. Alldritt
- Function : Author
J.S.B. Ramirez
- Function : Author
R. Vos de Wael
- Function : Author
R. Bethlehem
- Function : Author
J. Seidlitz
- Function : Author
Z. Wang
- Function : Author
K. Nenning
- Function : Author
N.B. Esper
- Function : Author
J. Smallwood
- Function : Author
A.R. Franco
- Function : Author
K. Byeon
- Function : Author
A. Alexander-Bloch
- Function : Author
D.G. Amaral
- Function : Author
C. Amiez
- Function : Author
F. Balezeau
- Function : Author
M.G. Baxter
- Function : Author
J. Bennett
- Function : Author
O. Berkner
- Function : Author
E.L.A. Blezer
- Function : Author
A.M. Brambrink
- Function : Author
Thomas Brochier
- Function : Author
- PersonId : 1412200
- ORCID : 0000-0001-6948-1234
B. Butler
- Function : Author
L.J. Campos
- Function : Author
Emmanuelle Canet-Soulas
- Function : Author
- PersonId : 841367
- IdHAL : emmanuelle-canet-soulas
- ORCID : 0000-0002-4742-5570
Lucie Chalet
- Function : Author
- PersonId : 1198133
- IdHAL : lucie-chalet
- ORCID : 0000-0002-8783-984X
A. Chen
- Function : Author
J. Cléry
- Function : Author
C. Constantinidis
- Function : Author
D.J. Cook
- Function : Author
Stanislas Dehaene
- Function : Author
- PersonId : 808498
- ORCID : 0000-0002-7418-8275
- IdRef : 03299690X
L. Dorfschmidt
- Function : Author
C.M. Drzewiecki
- Function : Author
J.W. Erdman
- Function : Author
S. Everling
- Function : Author
A. Falchier
- Function : Author
L. Fleysher
- Function : Author
A. Fox
- Function : Author
W. Freiwald
- Function : Author
Mathilda Froesel
- Function : Author
- PersonId : 1167319
- ORCID : 0000-0003-1222-6317
- IdRef : 261861670
S. Froudist-Walsh
- Function : Author
J. Fudge
- Function : Author
T. Funck
- Function : Author
Maëva Gacoin
- Function : Author
- PersonId : 1357581
- IdRef : 276039548
D.J. Gale
- Function : Author
J. Gallivan
- Function : Author
Clément M. Garin
- Function : Author
- PersonId : 1167318
- ORCID : 0000-0003-0712-7330
T.D. Griffiths
- Function : Author
Carole Guedj
- Function : Author
- PersonId : 1113095
Fadila Hadj-Bouziane
- Function : Author
- PersonId : 179465
- IdHAL : fadila-hadj-bouziane
- ORCID : 0000-0002-5415-7949
- IdRef : 197943969
Suliann Ben Hamed
- Function : Author
- PersonId : 178325
- IdHAL : suliann-ben-hamed
- ORCID : 0000-0003-1510-7284
- IdRef : 157262626
N. Harel
- Function : Author
R. Hartig
- Function : Author
Bassem Hiba
- Function : Author
- PersonId : 1059624
- IdHAL : bassem-hiba
- ORCID : 0000-0002-5436-3742
B.R. Howell
- Function : Author
Béchir Jarraya
- Function : Author
- PersonId : 1246670
- IdHAL : bechir-jarraya
- ORCID : 0000-0003-0878-763X
- IdRef : 098164864
B. Jung
- Function : Author
N. Kalin
- Function : Author
J. Karpf
- Function : Author
S. Kastner
- Function : Author
C. Klink
- Function : Author
Z.A. Kovacs-Balint
- Function : Author
C. Kroenke
- Function : Author
M.J. Kuchan
- Function : Author
S.C. Kwok
- Function : Author
K.N. Lala
- Function : Author
D.A. Leopold
- Function : Author
G. Li
- Function : Author
P. Lindenfors
- Function : Author
G. Linn
- Function : Author
R.B. Mars
- Function : Author
K. Masiello
- Function : Author
R.S. Menon
- Function : Author
A. Messinger
- Function : Author
M. Meunier
- Function : Author
K. Mok
- Function : Author
J.H. Morrison
- Function : Author
J. Nacef
- Function : Author
J. Nagy
- Function : Author
V. Neudecker
- Function : Author
M. Neuringer
- Function : Author
M.P. Noonan
- Function : Author
M. Ortiz-Rios
- Function : Author
J.F. Perez-Zoghbi
- Function : Author
C.I. Petkov
- Function : Author
M. Pinsk
- Function : Author
C. Poirier
- Function : Author
E. Procyk
- Function : Author
R. Rajimehr
- Function : Author
S.M. Reader
- Function : Author
D.A. Rudko
- Function : Author
M.F.S. Rushworth
- Function : Author
B.E. Russ
- Function : Author
J. Sallet
- Function : Author
M.M. Sanchez
- Function : Author
M.C. Schmid
- Function : Author
C.M. Schwiedrzik
- Function : Author
J.A. Scott
- Function : Author
J. Sein
- Function : Author
K.K. Sharma
- Function : Author
A. Shmuel
- Function : Author
M. Styner
- Function : Author
E.L. Sullivan
- Function : Author
A. Thiele
- Function : Author
O.S. Todorov
- Function : Author
D. Tsao
- Function : Author
A. Tusche
- Function : Author
R. Vlasova
- Function : Author
Z. Wang
- Function : Author
L. Wang
- Function : Author
J. Wang
- Function : Author
A.R. Weiss
- Function : Author
C.R.E. Wilson
- Function : Author
- PersonId : 182353
- IdHAL : charlie-wilson
- ORCID : 0000-0001-9497-919X
E. Yacoub
- Function : Author
W. Zarco
- Function : Author
Y. Zhou
- Function : Author
J. Zhu
- Function : Author
D. Margulies
- Function : Author
D. Fair
- Function : Author
C. Schroeder
- Function : Author
M. Milham
- Function : Author
T. Xu
- Function : Author
- PersonId : 1273655
- ORCID : 0000-0002-0065-3832
Abstract
Abstract Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for human brain development. However, similar models for nonhuman primate (NHP) growth are lacking. The rhesus macaque, a widely used NHP in translational neuroscience due to its similarities in brain anatomy, phylogenetics, cognitive, and social behaviors to humans, serves as an ideal NHP model. This study aimed to create normative growth charts for brain structure across the macaque lifespan, enhancing our understanding of neurodevelopment and aging, and facilitating cross-species translational research. Leveraging data from the PRIMatE Data Exchange (PRIME-DE) and other sources, we aggregated 1,522 MRI scans from 1,024 rhesus macaques. We mapped non-linear developmental trajectories for global and regional brain structural changes in volume, cortical thickness, and surface area over the lifespan. Our findings provided normative charts with centile scores for macaque brain structures and revealed key developmental milestones from prenatal stages to aging, highlighting both species-specific and comparable brain maturation patterns between macaques and humans. The charts offer a valuable resource for future NHP studies, particularly those with small sample sizes. Furthermore, the interactive open resource ( https://interspeciesmap.childmind.org ) supports cross-species comparisons to advance translational neuroscience research.
Domains
Neurons and Cognition [q-bio.NC]Origin | Files produced by the author(s) |
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licence |