The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation - Institut de Physique des 2 Infinis de Lyon Accéder directement au contenu
Article Dans Une Revue British Journal of Cancer Année : 2023

The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation

Résumé

Numerous studies have demonstrated the higher biological efficacy of carbon-ion irradiation (C-ions) and their ballistic precision compared with photons. At the nanometre scale, the reactive oxygen species (ROS) produced by radiation and responsible for the indirect effects are differentially distributed according to the type of radiation. Photon irradiation induces a homogeneous ROS distribution, whereas ROS remain condensed in clusters in the C-ions tracks. Based on this linear energy transfer-dependent differential nanometric ROS distribution, we propose that the higher biological efficacy and specificities of the molecular response to C-ions rely on a ‘stealth-bomber’ effect. When biological targets are on the trajectories of the particles, the clustered radicals in the tracks are responsible for a ‘bomber’ effect. Furthermore, the low proportion of ROS outside the tracks is not able to trigger the cellular mechanisms of defence and proliferation. The ability of C-ions to deceive the cellular defence of the cancer cells is then categorised as a ‘stealth’ effect. This review aims to classify the biological arguments supporting the paradigm of the ‘stealth-bomber’ as responsible for the biological superiority of C-ions compared with photons. It also explains how and why C-ions will always be more efficient for treating patients with radioresistant cancers than conventional radiotherapy.
Fichier principal
Vignette du fichier
BJC 2023.pdf (1.61 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03939645 , version 1 (15-01-2023)

Identifiants

Citer

Anne-Sophie Wozny, Claire Rodriguez-Lafrasse. The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation. British Journal of Cancer, 2023, 128, pp.1429-1438. ⟨10.1038/s41416-022-02117-6⟩. ⟨hal-03939645⟩
65 Consultations
30 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More