Novel genetic loci underlying human intracranial volume identified through genome-wide association - Institut Parisien de Chimie Moléculaire Accéder directement au contenu
Article Dans Une Revue Nature Neuroscience Année : 2016

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Hieab H H Adams (1) , Derrek P Hibar (2) , Vincent Chouraki (3, 4) , Jason L Stein (2) , Paul A Nyquist (5) , Miguel E Rentería (6) , Stella Trompet (7) , Alejandro Arias-Vasquez (8) , Sudha Seshadri (3) , Sylvane Desrivières (9) , Ashley H Beecham (10) , Neda Jahanshad (2) , Katharina Wittfeld (11, 12) , Sven J. van Der Lee (1) , Lucija Abramovic , Saud Alhusaini (13, 14) , Najaf Amin , Micael Andersson (15) , Konstantinos Arfanakis (16, 17) , Benjamin S Aribisala (18, 19) , Nicola J Armstrong (20, 21) , Lavinia Athanasiu (22) , Tomas Axelsson (23) , Alex Beiser (3, 24) , Bernard Bernard (25) , Joshua C Bis (26) , Laura Blanken (1) , Susan H Blanton (10) , Mar Bohlken , Mar Boks , Janita Bralten (27) , Adam M Brickman (28) , Owen Carmichael (29) , M Mallar Chakravarty (30, 31) , Ganesh Chauhan (32) , Qiang Chen (33) , Christophe Ching (2, 34) , Gabriel Cuellar-Partida (6) , Anouk Den Braber (35) , Nhat Trung Doan (22) , Stefan Ehrlich (36, 37) , Irina Filippi (38, 39) , Tian Ge (37, 40) , Sudheer Giddaluru (41, 42) , Aaron L Goldman (33) , Rebecca F Gottesman (43) , Corina U Greven (8, 9) , Oliver Grimm (44) , Michael E Griswold (45) , Tulio Guadalupe (46, 47) , Johanna Hass (36) , Unn K Haukvik , Saima Hilal (48) , Edith Hofer (49) , David Hoehn (50) , Avram J. Holmes (37, 51) , Martine Hoogman (8) , Deborah Janowitz (12) , Tianye Jia (9) , Dalia Kasperaviciute (52, 53) , Sungeun Kim (54) , Marieke Klein , Bernd Kraemer (55) , Phil H Lee (40) , Li Liao , David C Liewald (18) , Lorna M Lopez , Michelle Luciano (56) , Christine Macare (9) , Mar Marquand , Mar Matarin (57) , Karen A Mather (58) , Manuel Mattheisen (59, 60, 61) , Bernard Mazoyer (62) , David Mckay (63) , Rebekah Mcwhirter , Yuri Milaneschi (64) , Nazanin Mirza-Schreiber , Ryan L Muetzel (65) , Susana Muñoz Maniega , Kwangsik Nho (66, 67) , Allison C Nugent (68) , Loes M Olde Loohuis , Jaap Oosterlaan , Martina Martin , Irene Pappa , Lukas Pirpamer , Sara Pudas , Benno Pütz (69) , Kumar B Rajan (17) , Adaikalavan Ramasamy (70) , Jennifer S Richards , Shannon L Risacher (66, 67) , Robert Roiz-Santiañez (71) , Nanda Rommelse (27, 72) , Emma Rose (73) , Natalie A Royle (18) , Tatjana Rundek , Philipp G Sämann (50) , Claudia L Satizabal (74) , Li Schmaal (64) , Andrew Schork (75, 76) , Li Shen (67) , Jean Shin , Elena Shumskaya , Albert Smith , Emma Sprooten (63) , Lachlan T Strike (77, 78, 79) , Alex Teumer (80) , Russell Thomson , Diana Tordesillas-Gutierrez , Roberto Toro (81) , Daniah Trabzuni (82, 83) , Dhananjay Vaidya , Jeroen van Der Grond (84) , Dennis van Der Meer (85) , Marjolein M J van Donkelaar (27) , Kristel R van Eijk , Theo G M van Erp (86) , Daan van Rooij (87) , Esther Walton (88) , Lars Westlye (89) , Christophe Whelan , Beverly G Windham (22) , Anderson M Winkler (90) , Girma Woldehawariat (91) , Christiane Wolf , Thomas W Wolfers , Bing Xu , Lisa R Yanek (92) , Jingyun Yang , Alex Zijdenbos (93) , Marcel Zwiers (27) , Ingrid Agartz (94) , Neelum T Aggarwal , Laura Almasy (95) , David A Ames (96) , Philippe Amouyel (4) , Andreas Andreassen , Sampath Arepalli (97) , Amelia A Assareh (98) , Sandra Barral (99) , Mark Bastin (18) , Diane M Becker , James T Becker (100) , David A Bennett , John B Blangero (101, 102) , Hans van Bokhoven (103) , Dorret I Boomsma (80) , Henry Brodaty (104, 105) , Rachel M Brouwer (106) , Han G Brunner (107) , Randy L Buckner (108) , Jan K Buitelaar (87) , Kazima B Bulayeva (109) , Wiepke Cahn (110) , Vince D Calhoun (111, 112) , Dara M Cannon (113) , Gianpiero L Cavalleri (114) , Christophe Chen (115) , Ching-Yu Cheng , Sven Cichon (116, 117, 60, 61) , Mark Cookson (118) , Aiden Corvin (119, 120) , Benedicto Crespo-Facorro (71) , Joanne E Curran (121) , Michael Czisch (122) , Anders M Dale (123) , Gareth E Davies (35) , Eco J C de Geus (56) , Philip L de Jager (124, 125, 126) , Greig I de Zubicaray (127) , Norman Delanty (128, 129) , Chantal Depondt (130) , Anita L Destefano (131) , Allissa Dillman (132) , Srdjan Djurovic , Gary Donohoe (113, 120) , Wayne C Drevets (113) , Ravi Duggirala (102) , Thomas Dyer (101, 102) , Susanne Erk (133) , Thomas E Espeseth (89) , Denis A Evans , Iryna O Fedko (134) , Guillén Fernández , Luigi Ferrucci , Simon Fisher (87) , Debra A Fleischman (135) , Ian Ford , Tatiana M Foroud (136) , Peter Fox (101, 137) , Clyde Francks (47, 27) , Masaki Fukunaga (138) , J Raphael Gibbs (139) , David C Glahn (63) , Randy L Gollub (140) , Harald H H Göring (141) , Hans J Grabe (142) , Robert Green (143) , Oliver Gruber , Vilmundur Gudnason (144, 145) , Sebastian Guelfi (83) , Narelle K Hansell (56) , John Hardy (146) , Catharina A Hartman (56) , Ryota Hashimoto (147) , Katrin Hegenscheid (12) , Andreas Heinz , Stephanie Le Hellard , Dena G Hernandez , Dirk J Heslenfeld (12) , Beng-Choon Ho (148) , Pieter J Hoekstra (149) , Wolfgang Hoffmann , Albert Hofman , Florian Holsboer (150) , Georg Homuth (151) , Norbert Hosten (12) , Jouke-Jan Hottenga (80) , Hilleke E Hulshoff Pol , Masashi Ikeda (152) , M Kamran Ikram (153) , Clifford R Jack Jr , Mark Jenkinson , Robert Johnson (154) , Erik G Jönsson (155, 156) , J Wouter Jukema (157) , René S Kahn , Ryota Kanai (158, 159) , Iwona Kloszewska (160) , David S Knopman (161) , Peter Kochunov (162) , John B Kwok (163) , Stephen M Lawrie (18) , Hervé Lemaître (164) , Xinmin Liu , Dan L Longo (165) , W T Longstreth Jr , Oscar L Lopez (166) , Simon Lovestone (167) , Oliver Martin , Jean-Luc Martin , Venkata S Mattay (168) , Colm Mcdonald (169) , Andrew Mcintosh (170) , Katie L Mcmahon (171) , Francis J Mcmahon , Patrizia Mecocci (172) , Ingrid Melle (173, 174, 175, 94) , Andreas Meyer-Lindenberg (176) , Sebastian Mohnke (177) , Grant W Montgomery (79, 178) , Derek W Morris (179) , Thomas H Mosley , Thomas W Mühleisen (60, 61) , Bertram Müller-Myhsok (180) , Michael A Nalls (181) , Matthias Nauck (182) , Thomas E Nichols (183, 184) , Wiro J Niessen (185) , Markus M Nöthen (186) , Lars Nyberg (187) , Kazutaka Ohi (188) , Rene L Olvera (189) , Roel A Ophoff (190) , Massimo Pandolfo (130) , Tomas Paus (191) , Zdenka Pausova (192) , Brenda W J H Penninx (178) , G Bruce Pike , Steven G Potkin (193) , Bruce M Psaty (194) , Simone Reppermund (105) , Marcel Rietschel (195, 196) , Joshua L Roffman (197) , Nina Romanczuk-Seiferth (177) , Jerome I Rotter (198) , Mina Ryten (199, 83) , Ralph L Sacco (115) , Perminder S Sachdev (200) , Andrew Saykin (177, 66, 67) , Reinhold Schmidt , Peter R Schofield (201) , Sigurdur Sigurdsson (202, 203) , Andy Simmons , Andrew Singleton (181) , Sanjay M Sisodiya (204) , Colin Smith , Jordan W Smoller (37) , Hilkka Soininen (205) , Velandai Srikanth (206, 207) , Vidar M Steen , David J Stott (208) , Jessika E Sussmann (18) , Anbupalam Thalamuthu (209) , Henning Tiemeier (210) , Arthur W Toga (211) , Bryan J Traynor (212) , Juan Troncoso , Jessica A Turner (213) , Christophe Tzourio (214) , Andre G Uitterlinden , Maria C Valdés Hernández , Marcel van Der Brug (215) , Aad van Der Lugt (216) , Nic J A van Der Wee (217) , Cornelia M van Duijn , Neeltje E M van Haren , Dennis van ′t Ent , Marie-Jose van Tol (7) , Badri N Vardarajan , Dick J Veltman (64) , Meike W Vernooij (218, 216) , Henry Völzke (219) , Henrik Walter (177, 220) , Joanna M Wardlaw (18) , Thomas H Wassink (221) , Michael E Weale (222) , Wei Weinberger , Wei Weiner , Wei Wen (223) , Eric Westman (224) , Tonya White (225) , Tien y Wong (226) , Clinton B Wright (227) , H Ronald Zielke , Alan B Zonderman (91) , Ian J Deary (18) , Charles Decarli (228) , Helena Schmidt (229) , Nicholas G Martin , Anton J M de Craen (230) , Margaret J Wright (231) , Lenore J Launer , Gunter Schumann (232) , Myriam Fornage (101, 233) , Barbara Franke (87) , Stéphanie Debette (214) , Sarah E Medland (79) , M Arfan Ikram , Paul M Thompson (2)
1 Erasmus MC - Erasmus University Medical Center [Rotterdam]
2 Keck School of Medicine [Los Angeles]
3 BUSM - Boston University School of Medicine
4 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
5 JHU - Johns Hopkins University
6 QIMR Berghofer Medical Research Institute
7 LUMC - Leiden University Medical Center
8 Radboud University Medical Center [Nijmegen]
9 Institute of Psychiatry, Psychology & Neuroscience, King's College London
10 UMMSM - University of Miami Leonard M. Miller School of Medicine
11 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
12 Greifswald University Hospital
13 Department of Neurology and Neurosurgery [Montreal]
14 RCSI - Royal College of Surgeons in Ireland
15 Umeå University
16 IIT - Illinois Institute of Technology
17 Rush University Medical Center [Chicago]
18 Edin. - University of Edinburgh
19 LASU - Lagos State University
20 UNSW - University of New South Wales [Sydney]
21 Murdoch University
22 UiO - University of Oslo
23 Uppsala University
24 Framingham Heart Study
25 University of Toronto
26 University of Washington [Seattle]
27 Donders Institute for Brain, Cognition and Behaviour
28 CUMC - Columbia University Medical Center
29 Pennington Biomedical Research Center
30 Montreal Neurological Institute and Hospital
31 McGill University = Université McGill [Montréal, Canada]
32 BPH - Bordeaux population health
33 LIBD - Lieber Institute for Brain Development [Baltimore]
34 UCLA - University of California [Los Angeles]
35 VU - Vrije Universiteit Amsterdam [Amsterdam]
36 TU Dresden - Technische Universität Dresden = Dresden University of Technology
37 Massachusetts General Hospital [Boston]
38 U1000 - Neuroimagerie en psychiatrie
39 Maison de Solenn [CHU Cochin]
40 BROAD INSTITUTE - Broad Institute of MIT and Harvard
41 UiB - University of Bergen
42 Haukeland University Hospital
43 Johns Hopkins University School of Medicine [Baltimore]
44 Universität Heidelberg [Heidelberg] = Heidelberg University
45 UMMC - University of Mississippi Medical Center
46 IMPRS - International Max Planck Research School for Language Sciences
47 Language and Genetics Department [Nijmegen]
48 NUS - National University of Singapore
49 Medical University Graz
50 Max Planck Institute of Psychiatry
51 Yale University [New Haven]
52 UCL - University College of London [London]
53 Imperial College London
54 SRSMC - Structure et Réactivité des Systèmes Moléculaires Complexes
55 Georg-August-University = Georg-August-Universität Göttingen
56 Medstar Research Institute
57 Clinical And Experimental Epilepsy
58 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
59 Department of Biomedicine and the Centre for Integrative Sequencing
60 Institute of Human Genetics
61 Department of Genomics, Life and Brain Center
62 GIN - [GIN] Grenoble Institut des Neurosciences
63 Dpt of Psychiatry [New Haven]
64 Department of Psychiatry
65 Department of Psychology [Minneapolis]
66 Indiana Alzheimer Disease Center
67 Indiana University School of Medicine
68 Institute of Food & Health, University College Dublin,
69 Statistical Genetics Group
70 Respiratory Epidemiology and Public Health
71 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
72 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]
73 IPCM - Institut Parisien de Chimie Moléculaire
74 INSERM, Neuroepidemiology U708, Bordeaux, France
75 CogSci - UC San Diego - Department of Cognitive Sciences [Univ California San Diego]
76 Neuro - UC San Diego - Department of Neurosciences [Univ California San Diego]
77 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia
78 School of Psychology, University of Queensland, Brisbane 4072, Australia
79 Queensland Institute of Medical Research
80 King‘s College London
81 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
82 Department of Genetics
83 Reta Lila Weston Institute of Neurological Studies
84 Depts of Radiology
85 University of Twente
86 Department of Psychiatry and Human Behavior [Irvine]
87 Donders Center for Cognitive Neuroimaging
88 EDC - Centre épigénétique et destin cellulaire
89 Department of Psychology [Oslo]
90 Deutsche Bundesbank
91 NIH - National Institutes of Health [Bethesda, MD, USA]
92 General Internal Medicine, Johns Hopkins School of Medicine
93 Biospective [Montréal]
94 KG Jebsen Centre for Psychosis Research
95 Department of Genetics
96 Department of Psychiatry and National Ageing Research Institute
97 Department of Clinical Genetics
98 Department of Medical Parasitology and Mycology
99 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
100 Departments of Psychiatry, Neurology, and Psychology
101 UTHealth - The University of Texas Health Science Center at Houston
102 Texas Biomedical Research Institute [San Antonio, TX]
103 849 Department of Human Genetics
104 Dementia Collaborative Research Centre
105 Centre for Healthy Brain Ageing
106 Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands
107 UNIL - Université de Lausanne = University of Lausanne
108 Department of Psychiatry [Boston]
109 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
110 Department of Psychiatry
111 The Mind Research Network
112 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
113 Human Genetics Branch
114 Division of Molecular and Cellular Therapeutics
115 Metacohorts Consortium
116 Division of Medical Genetics
117 INM-1 - Institute of Neuroscience and Medicine
118 Cell Biology and Gene Expression Section
119 Neuropsychiatric Genetics Research Group
120 Department of Psychiatry
121 Department of Materials Science & Metallurgy
122 Bijvoet Center of Biomolecular Research [Utrecht]
123 UC San Diego - University of California [San Diego]
124 Program in Translational NeuroPsychiatric Genomics,
125 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
126 HMS - Harvard Medical School [Boston]
127 School of Psychology, University of Queensland
128 Neurology Division, Beaumont Hospital, Dublin 9, Ireland
129 Molecular and Cellular Therapeutics
130 Department of Neurology
131 BU - Boston University [Boston]
132 Laboratory of Neurogenetics
133 Department of Genomics
134 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands
135 Department of Radiology
136 Department of Medical and Molecular Genetics
137 South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
138 Department of Physics, Okayama University
139 Laboratory of Neurogenetics
140 Athinoula A. Martinos Center for Biomedical Imaging
141 Public Health Genomics Unit
142 Department of Psychiatry and Psychotherapy
143 Department of Mathematics, University of Colorado
144 Icelandic Heart Association, Kopavogur, Iceland.
145 Faculty of Medicine
146 Department of Molecular Neurosciences
147 Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development,
148 Department of Psychiatry, University of Iowa
149 Department of Psychiatry
150 Neuronal Plasticity / Mouse Behaviour
151 Interfaculty Institute for Genetics and Functional Genomics
152 Tohoku University [Sendai]
153 Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
154 SBU - Stony Brook University [SUNY]
155 Department of Medicine, Clinical Pharmacology Unit
156 Centre for Allergy Research
157 Interuniversity Cardiology Institute Netherlands
158 Institute of Cognitive Neuroscience
159 University of Sussex
160 MUL - Medical University of Łódź
161 Department of Neurology
162 Department of Psychiatry
163 Department of Civil and Structural Engineering
164 UCP - Université de Cergy Pontoise
165 Lymphocyte Cell Biology Unit, Laboratory of Genetics
166 LSTA - Laboratoire de Statistique Théorique et Appliquée
167 Psychiatry Institute
168 Department of Health and Human Services
169 Department of Life Sciences
170 MSI - Mathematical Sciences Institute
171 Centre for Advanced Imaging
172 Institute of Gerontology and Geriatrics
173 Division of Mental Health and Addiction
174 Institute of Clinical Medicine [Oslo]
175 Division of Mental Health and Addiction
176 University Hospital Mannheim | Universitätsmedizin Mannheim
177 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
178 Genetic Epidemiology Unit
179 UTLN UFR LSH - Université de Toulon - UFR Lettres et Sciences Humaines
180 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
181 Laboratory of Neurogenetics
182 Institute of Clinical Chemistry and Laboratory Medicine
183 WMG - Warwick Manufacturing Group [Coventry]
184 Department of Statistics [Warwick]
185 TU Delft - Delft University of Technology
186 Rheinische Friedrich-Wilhelms-Universität Bonn
187 Department of Health Science, Division of Health and Rehabilitation
188 Department of Psychiatry
189 Department of Medical and Molecular Genetics
190 Department of Psychiatry
191 MNI - McConnell Brain Imaging Centre
192 Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada
193 Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA
194 Group Health Research Institute, Group Health Cooperative
195 Department of Psychiatry
196 Department of Genetic Epidemiology in Psychiatry
197 Department of Psychiatry
198 Cedars-Sinai Medical Center
199 Department of Medical and Molecular Genetics
200 Centre for Healthy Brain Ageing [Sydney]
201 Genetics of Mental Illness and Brain Function
202 Broad Institute [Cambridge]
203 Department of Medical Biochemistry and Microbiology
204 Department of Clinical and Experimental Epilepsy
205 University of Eastern Finland
206 Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University
207 Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
208 Institute of Cardiovascular and Medical Sciences [Glasgow]
209 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia
210 Department of Epidemiology
211 LONI - Laboratory of Neuro Imaging [Los Angeles]
212 National Institute of Aging
213 University of York [York, UK]
214 Epidémiologie et Biostatistique [Bordeaux]
215 Genentech, Inc. [San Francisco]
216 Departments of Radiology and of Epidemiology [Rotterdam]
217 Psychiatry and Leiden Institute for Brain and Cognition
218 Department of Neurology [Rotterdam]
219 Institute for Community Medicine
220 Berlin School of Mind and Brain [Berlin]
221 Department of Psychiatry
222 Centre for Population Health Sciences
223 Department of Physics [Hong Kong University of Science and Technology]
224 Department of Neurobiology, Care Sciences and Society
225 Research Laboratory for Archaeology & the History of Art
226 Singapore Eye Research Institute, Singapore National Eye Centre
227 School of Life Sciences
228 Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento
229 Dpt of Pharmacology and Personalised Medicine [Maastricht]
230 Department of neurology
231 Mizzou - University of Missouri [Columbia]
232 Göttingen Zentrum Geowissenschaften
233 Human Genetics Center
Lucija Abramovic
  • Fonction : Auteur
Najaf Amin
  • Fonction : Auteur
Mar Bohlken
  • Fonction : Auteur
Mar Boks
  • Fonction : Auteur
Unn K Haukvik
  • Fonction : Auteur
Marieke Klein
  • Fonction : Auteur
Li Liao
  • Fonction : Auteur
Lorna M Lopez
  • Fonction : Auteur
Mar Marquand
  • Fonction : Auteur
Bernard Mazoyer
Rebekah Mcwhirter
  • Fonction : Auteur
Nazanin Mirza-Schreiber
  • Fonction : Auteur
Susana Muñoz Maniega
  • Fonction : Auteur
Loes M Olde Loohuis
  • Fonction : Auteur
Jaap Oosterlaan
  • Fonction : Auteur
Martina Martin
  • Fonction : Auteur
Irene Pappa
  • Fonction : Auteur
Lukas Pirpamer
  • Fonction : Auteur
Sara Pudas
  • Fonction : Auteur
Jennifer S Richards
  • Fonction : Auteur
Tatjana Rundek
  • Fonction : Auteur
Jean Shin
  • Fonction : Auteur
Elena Shumskaya
  • Fonction : Auteur
Albert Smith
  • Fonction : Auteur
Russell Thomson
  • Fonction : Auteur
Diana Tordesillas-Gutierrez
  • Fonction : Auteur
Dhananjay Vaidya
  • Fonction : Auteur
Dennis van Der Meer
Kristel R van Eijk
  • Fonction : Auteur
Christophe Whelan
  • Fonction : Auteur
Christiane Wolf
  • Fonction : Auteur
Thomas W Wolfers
  • Fonction : Auteur
Bing Xu
  • Fonction : Auteur
Jingyun Yang
  • Fonction : Auteur
Neelum T Aggarwal
  • Fonction : Auteur
Laura Almasy
Andreas Andreassen
  • Fonction : Auteur
Diane M Becker
  • Fonction : Auteur
David A Bennett
  • Fonction : Auteur
Ching-Yu Cheng
  • Fonction : Auteur
Srdjan Djurovic
  • Fonction : Auteur
Denis A Evans
  • Fonction : Auteur
Guillén Fernández
  • Fonction : Auteur
Luigi Ferrucci
  • Fonction : Auteur
Ian Ford
  • Fonction : Auteur
Oliver Gruber
  • Fonction : Auteur
Andreas Heinz
  • Fonction : Auteur
Stephanie Le Hellard
  • Fonction : Auteur
Dena G Hernandez
  • Fonction : Auteur
Wolfgang Hoffmann
  • Fonction : Auteur
Albert Hofman
  • Fonction : Auteur
Hilleke E Hulshoff Pol
  • Fonction : Auteur
Clifford R Jack Jr
  • Fonction : Auteur
Mark Jenkinson
  • Fonction : Auteur
René S Kahn
  • Fonction : Auteur
Xinmin Liu
  • Fonction : Auteur
W T Longstreth Jr
  • Fonction : Auteur
Oliver Martin
  • Fonction : Auteur
Jean-Luc Martin
  • Fonction : Auteur
Francis J Mcmahon
  • Fonction : Auteur
Thomas H Mosley
  • Fonction : Auteur
G Bruce Pike
  • Fonction : Auteur
Reinhold Schmidt
  • Fonction : Auteur
Andy Simmons
  • Fonction : Auteur
Colin Smith
  • Fonction : Auteur
Hilkka Soininen
Vidar M Steen
  • Fonction : Auteur
Henning Tiemeier
Juan Troncoso
  • Fonction : Auteur
Andre G Uitterlinden
  • Fonction : Auteur
Maria C Valdés Hernández
  • Fonction : Auteur
Cornelia M van Duijn
  • Fonction : Auteur
Neeltje E M van Haren
  • Fonction : Auteur
Dennis van ′t Ent
  • Fonction : Auteur
Badri N Vardarajan
  • Fonction : Auteur
Wei Weinberger
  • Fonction : Auteur
Wei Weiner
  • Fonction : Auteur
H Ronald Zielke
  • Fonction : Auteur
Nicholas G Martin
  • Fonction : Auteur
Lenore J Launer
  • Fonction : Auteur
M Arfan Ikram
  • Fonction : Auteur correspondant
  • PersonId : 1041560

Connectez-vous pour contacter l'auteur

Résumé

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.

Dates et versions

hal-01382716 , version 1 (17-10-2016)

Identifiants

Citer

Hieab H H Adams, Derrek P Hibar, Vincent Chouraki, Jason L Stein, Paul A Nyquist, et al.. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩. ⟨hal-01382716⟩
1189 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More