RAFT-polymerized N-cyanomethylacrylamide-based (co)polymers exhibiting tunable UCST behavior in water - Institut Parisien de Chimie Moléculaire Accéder directement au contenu
Article Dans Une Revue Macromolecular Rapid Communications Année : 2021

RAFT-polymerized N-cyanomethylacrylamide-based (co)polymers exhibiting tunable UCST behavior in water

Résumé

In this present work, the synthesis of a new family of upper critical solution temperature (UCST)-thermoresponsive polymers based on N-cyanomethylacrylamide (CMAm) is reported. It is demonstrated that the thermally initiated reversible addition fragmentation chain transfer (RAFT) polymerization of CMAm conducted in N,N-dimethylformamide (DMF) is well controlled. The homopolymer presents a sharp and reversible UCST-type phase transition in pure water with a very small hysteresis between cooling and heating cycles. It is demonstrated that the cloud point (TCP) of poly(N-cyanomethylacrylamide) (PCMAm) is strongly molar mass dependent and shifts toward lower temperatures in saline water. Moreover, the transition temperature can be tuned over a large temperature range by copolymerization of CMAm with acrylamide or acrylic acid. The latter copolymers are both thermoresponsive and pH responsive. Interestingly, by this strategy sharp and reversible UCST-type transitions close to physiological temperature can be reached, which makes the copolymers extremely interesting candidates for biomedical applications.

Domaines

Chimie
Fichier principal
Vignette du fichier
Audureau et al. - RAFT-Polymerized N-Cyanomethylacrylamide-Based (Co.pdf (1.08 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03388766 , version 1 (20-10-2021)

Identifiants

Citer

Nicolas Audureau, Clémence Veith, Fanny Coumes, Thi Phuong Thu Nguyen, Jutta Rieger, et al.. RAFT-polymerized N-cyanomethylacrylamide-based (co)polymers exhibiting tunable UCST behavior in water. Macromolecular Rapid Communications, 2021, pp.2100556. ⟨10.1002/marc.202100556⟩. ⟨hal-03388766⟩
540 Consultations
91 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More