NF-X, a transcription factor implicated in MHC class II gene regulation. - BIG - Chimie et Biologie des Métaux (CBM) Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 1991

NF-X, a transcription factor implicated in MHC class II gene regulation.

V Kouskoff
  • Fonction : Auteur
R Mantovani
  • Fonction : Auteur
A Staub
  • Fonction : Auteur
B Lisowska-Grospierre
  • Fonction : Auteur
C Griscelli
  • Fonction : Auteur
C. Benoist
  • Fonction : Auteur
D Mathis
  • Fonction : Auteur

Résumé

The X box has been shown in several assay systems to be a critical element of MHC class II gene promoters. Several X box-binding activities have been discovered in nuclear extracts from a variety of cell lines. The critical question is: which of these are responsible for mediating X box function? This report provides a further characterization of NF-X, a highly specific X box-binding activity we described previously. The cell-type distribution, structural features, and binding site characteristics of NF-X are analyzed in detail, to facilitate comparison with other reported activities. Most importantly, the functional relevance of NF-X is assessed by scanning mutagenesis, and the results indicate that this complex is indeed involved in regulating MHC class II gene expression. With these data in mind, the relationship between NF-X and RF-X, an X box-binding activity reported to be absent in patients with severe combined immunodeficiency, is discussed.
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Dates et versions

hal-01949125 , version 1 (08-01-2020)

Identifiants

  • HAL Id : hal-01949125 , version 1
  • PUBMED : 2016543

Citer

V Kouskoff, R Mantovani, Serge M. Candéias, A Staub, B Lisowska-Grospierre, et al.. NF-X, a transcription factor implicated in MHC class II gene regulation.. Journal of Immunology, 1991, 146 (9), pp.3197-204. ⟨hal-01949125⟩
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