A new tool to study genetic expression using 2-D electrophoresis data: the functional map concept
Résumé
A method derived from general computerized data analysis techniques is used here first to tabulate the characteristics of individual peptide spots observed by two-dimensional electrophoresis and to compare these characteristics among spots. Multivariate analysis of such data arrays then leads to the grouping of spots in an n-dimensional space, according to their expression characteristics. Such maps display zones which are characteristic of the tissue studied. These functional maps provide a powerful analytical tool for describing such functional interactions and also for predicting the function of unidentified peptides observed on the electrophoresis gels.
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FEBS Letters - September 23 1985 - Rabilloud - A new tool to study genetic expression using 2%E2%80%90D electrophoresis data the.pdf (579.46 Ko)
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