Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis - Laboratoire de psychologie sociale et de psychologie cognitive Accéder directement au contenu
Article Dans Une Revue Atherosclerosis Année : 2020

Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis

Résumé

Background and aimsShift work is common worldwide and linked to deleterious cardiovascular effects that might be underlined by dyslipidemia. The aim of this systematic review and meta-analysis is to determine the impact of shiftwork on dyslipidemia.MethodsSearching in PubMed, Cochrane Library, Science Direct and Embase databases without language restriction on 15 February 2020, included studies that describe blood lipids levels or a risk measure in shift workers compared with fixed-day workers (controls). Differences by study-level characteristics were estimated using stratified meta-analysis by type of shift work, and meta-regression to examine relations between dyslipidemia and demographic, lifestyle and work characteristics. Estimates were pooled using random-effect meta-analysis.ResultsWe included a total of 66 articles, representing 197,063 workers. Shift work globally increased the levels of triglycerides (overall SMD = 0.09; 95CI 0.05 to 0.13; p < 0.001), and globally decreased the levels of c-HDL (−0.08; 95CI −0.12 to −0.03; p = 0.001). Permanent night shift workers were an at-risk type of shift for dyslipidemia with significantly higher blood levels of total cholesterol (0.22; 95CI 0.01 to 0.42; p = 0.043) and triglycerides (0.18; 0.03 to 0.33; p = 0.017), and significantly lower blood levels of c-HDL (−0.16; 95CI −0.32 to 0.00; p = 0.05). Permanent night shift workers were more at-risk for total cholesterol than rotating 3 × 8 shift workers (Coefficient 0.22; 95CI 0.01 to 0.42; p = 0.038) and rotating 2 × 12 shift workers (0.24; 0.02 to 0.46; p = 0.037), and more at-risk for triglycerides than rotating day shift workers (0.21; 95CI 0.03 to 0.38; p = 0.023). Results were non-significant for c-LDL, nor depending on type of shifts.ConclusionsShift work, and particularly permanent night shift, is associated with dyslipidaemia via elevated total cholesterol and triglycerides, and reduced HDL-cholesterol. Our current study provides a practical and valuable strengthening of the evidence-base required for preventive health initiatives and workplace reform.
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hal-03031098 , version 1 (17-10-2022)

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Paternité - Pas d'utilisation commerciale

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Frédéric Dutheil, Julien S. Baker, Martial Mermillod, Mélanie de Cesare, Alexia Vidal, et al.. Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis. Atherosclerosis, 2020, 313, pp.156-169. ⟨10.1016/j.atherosclerosis.2020.08.015⟩. ⟨hal-03031098⟩
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