Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs - Laboratoire des Interactions Plantes Microbes Environnement Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2017

Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs

Résumé

Lipo-chitotetrasaccharide analogues where one central GlcNAc residue was replaced by a triazole unit have been synthesized from a derivative obtained by chitin depolymerization and a functionalized N-acetyl-glucosamine via the copper-catalyzed azide-alkyne cycloaddition. Their evaluation in a binding assay using LYR3, a putative lipo-chitooligosaccharide receptor in Medicago truncatula, shows a complete loss of binding.

Domaines

Chimie organique
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Dates et versions

hal-02626296 , version 1 (26-05-2020)

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Nathan Berthelot, Antoine Brossay, Virginie Gasciolli, Jean-Jacques Bono, Aurélie Baron, et al.. Synthesis of lipo-chitooligosaccharide analogues and their interaction with LYR3, a high affinity binding protein for Nod factors and Myc-LCOs. Organic & Biomolecular Chemistry, 2017, 15 (37), pp.7802-7812. ⟨10.1039/c7ob01201b⟩. ⟨hal-02626296⟩
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