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Article Dans Une Revue Physical Review E : Statistical, Nonlinear, and Soft Matter Physics Année : 2008

Cluster phases of membrane proteins

Résumé

A physical scenario accounting for the existence of size-limited submicrometric domains in cell membranes is proposed. It is based on the numerical investigation of the counterpart, in lipidic membranes where proteins are diffusing, of the recently discovered cluster phases in colloidal suspensions. I demonstrate that the interactions between proteins, namely short-range attraction and longer-range repulsion, make possible the existence of stable small clusters. The consequences are explored in terms of membrane organization and diffusion properties. The connection with lipid rafts is discussed and the apparent protein diffusion coefficient as a function of their concentration is analyzed.

Dates et versions

hal-00417503 , version 1 (16-09-2009)

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Nicolas Destainville. Cluster phases of membrane proteins. Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, 2008, 77 (1), pp.011905. ⟨10.1103/PhysRevE.77.011905⟩. ⟨hal-00417503⟩
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