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Article Dans Une Revue Biochimica et Biophysica Acta:Biomembranes Année : 2011

Electromediated formation of DNA complexes with cell membranes and its consequences for gene delivery

Résumé

Electroporation is a physical method to induce the uptake of therapeutic drugs and DNA, by eukaryotic cells and tissues. The phenomena behind electro-mediated membrane permeabilization to plasmid DNA have been shown to be significantly more complex than those for small molecules. Small molecules cross the permeabilized membrane by diffusion whereas plasmid DNA first interacts with the electropermeabilized part of the cell surface, forming localized aggregates. The dynamics of this process is still poorly understood because direct observations have been limited to scales of
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hal-00998724 , version 1 (19-03-2021)

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Jean-Michel Escoffre, Thomas Portet, Cyril Favard, Justin Teissié, David S. Dean, et al.. Electromediated formation of DNA complexes with cell membranes and its consequences for gene delivery. Biochimica et Biophysica Acta:Biomembranes, 2011, 1808 (6), pp.1538-1543. ⟨10.1016/j.bbamem.2010.10.009⟩. ⟨hal-00998724⟩
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