Pharmacological advances in mitochondrial therapy - Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques
Article Dans Une Revue EBioMedicine Année : 2021

Pharmacological advances in mitochondrial therapy

Résumé

Mitochondria play a vital role in cellular metabolism and are central mediator of intracellular signalling, cell differentiation, morphogenesis and demise. An increasingly higher number of pathologies is linked with mitochondrial dysfunction, which can arise from either genetic defects affecting core mitochondrial components or malfunctioning pathways impairing mitochondrial homeostasis. As such, mitochondria are considered an important target in several pathologies spanning from neoplastic to neurodegenerative diseases as well as metabolic syndromes. In this review we provide an overview of the state-of-the-art in mitochondrial pharmacology, focusing on the novel compounds that have been generated in the bid to correct mitochondrial aberrations. Our work aims to serve the scientific community working on translational medical science by highlighting the most promising pharmacological approaches to target mitochondrial dysfunction in disease.

Fichier principal
Vignette du fichier
Pharmacological advances in mitochondrial therapy.pdf (504.36 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-04804499 , version 1 (26-11-2024)

Identifiants

Citer

Aarti Singh, Danilo Faccenda, Michelangelo Campanella. Pharmacological advances in mitochondrial therapy. EBioMedicine, 2021, 65, ⟨10.1016/j.ebiom.2021.103244⟩. ⟨hal-04804499⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

More