Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma - Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques
Article Dans Une Revue Cells Année : 2022

Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma

Hong-Toan Lai
Reynand Jay Canoy
  • Fonction : Auteur
Michelangelo Campanella
Yegor Vassetzky

Résumé

Hepatocellular carcinoma (HCC) is a type of liver cancer with a poor prognosis for survival given the complications it bears on the patient. Though damages to the liver are acknowledged prodromic factors, the precise molecular aetiology remains ill-defined. However, many genes coding for proteins involved in calcium (Ca 2+ ) homeostasis emerge as either mutated or deregulated. Ca 2+ is a versatile signalling messenger that regulates functions that prime and drive oncogenesis, favouring metabolic reprogramming and gene expression. Ca 2+ is present in cell compartments, between which it is trafficked through a network of transporters and exchangers, known as the Ca 2+ transportome. The latter regulates and controls Ca 2+ dynamics and tonicity. In HCC, the deregulation of the Ca 2+ transportome contributes to tumorigenesis, the formation of metastasizing cells, and evasion of cell death. In this review, we reflect on these aspects by summarizing the current knowledge of the Ca 2+ transportome and overviewing its composition in the plasma membrane, endoplasmic reticulum, and the mitochondria.

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Dates et versions

hal-04805144 , version 1 (26-11-2024)

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Hong-Toan Lai, Reynand Jay Canoy, Michelangelo Campanella, Yegor Vassetzky, Catherine Brenner. Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma. Cells, 2022, 11, ⟨10.3390/cells11050815⟩. ⟨hal-04805144⟩
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