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Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2020

Effect of Alzheimer’s disease‐related β‐amyloid peptide conformations in transgenic mouse models of β‐amyloidosis

Marina Célestine
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Muriel Jacquier‐sarlin
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Eve Borel
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Anne‐sophie Herard
  • Fonction : Auteur
Alain Buisson
  • Fonction : Auteur

Résumé

Background: Alzheimer's disease (AD) brain dysfunctions are not exclusively related to amyloid plaques occurence, but are thought to start much earlier, presumably due to soluble pathological forms of b-amyloid peptide (Aβ). Indeed Aβ oligomers induce synaptic dysfunctions that cause cognitive decline, exacerbate tau pathology[1] and influence neuronal networks[2]. Although mutation-induced phenotypes are identified in AD patients, the in vivo effects of different Aβ variants are poorly understood. Here we characterized the effects of different Aβ variants in a transgenic mouse model to provide deeper insight of transconformational processes and the subsequent alterations. Deciphering Ab profiles would help in developing new diagnostic and therapeutic approaches. References: (1) Delacourte et al., Experimental Gerontology, 2002. (2) Bero et al., Journal of Neuroscience, 2012.

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Neurobiologie
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hal-03453388 , version 1 (28-11-2021)

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Marina Célestine, Muriel Jacquier‐sarlin, Eve Borel, Anne‐sophie Herard, Alain Buisson, et al.. Effect of Alzheimer’s disease‐related β‐amyloid peptide conformations in transgenic mouse models of β‐amyloidosis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2020, 16 (S2), ⟨10.1002/alz.043415⟩. ⟨hal-03453388⟩
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