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Article Dans Une Revue Magnetic Resonance in Medicine Année : 2022

Assessing potential correlation between T 2 relaxation and diffusion of lactate in the mouse brain

Résumé

While diffusion and T 2 relaxation are intertwined, little or no correlation exists between diffusion and T 2 relaxation of intracellular metabolites in the rodent brain, as measured by diffusion-weighted MRS at different TEs. However, situation might be different for lactate, since it is present in both extracellular and intracellular spaces, which exhibit different diffusion properties and may also exhibit different T 2. Such a TE dependence would be crucial to account for when interpreting or modeling lactate diffusion. Here we propose to take advantage of a new diffusion sequence, where J-modulation of lactate is canceled even at long TE, thus retaining excellent signal, to assess potential T 2 dependence on diffusion of lactate in the mouse brain. Methods: Using a frequency-selective diffusion-weighted spin-echo sequence that removes J-modulation at 1.3 ppm, thus preserving lactate signal even at long TE, we investigate the effect of TE between 50.9 and 110.9 ms (while keeping diffusion time constant) on apparent diffusivity and kurtosis in the mouse brain. Results: Regardless of the metabolites, no difference appears for the diffusion-weighted signal attenuation with increasing TE. For lactate, apparent diffusivity and kurtosis remain unchanged as TE increases. Conclusion: No significant TE dependence of diffusivity and kurtosis is measured for lactate in the 50-110 ms TE range, confirming that potential T 2 effects can be ignored when interpreting or modeling lactate diffusion.
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Dates et versions

hal-03745887 , version 1 (04-08-2022)

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Eloïse Mougel, Sophie Malaquin, Julien Valette. Assessing potential correlation between T 2 relaxation and diffusion of lactate in the mouse brain. Magnetic Resonance in Medicine, 2022, ⟨10.1002/mrm.29395⟩. ⟨hal-03745887⟩
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