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LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons

Kevin Burbidge , David J. Rademacher , Jessica Mattick , Stephanie Zack , Andrea Grillini et al.
Autophagy, 2021, pp.1-29. ⟨10.1080/15548627.2021.1967615⟩
Journal articles cea-03384708v1
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Transmission of Alzheimer pathology in murine and primate models : from proteinopathies to neuronal and cognitive impairments

Suzanne Lam
Neuroscience. Université Paris-Saclay, 2021. English. ⟨NNT : 2021UPASL063⟩
Theses tel-03656231v1
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Reduced and stable feature sets selection with random forest for neurons segmentation in histological images of macaque brain

Clément Bouvier , Nicolas Souedet , Joshua J. Levy , Caroline Jan , Zhenzhen You et al.
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-02344-6⟩
Journal articles hal-03487752v1
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Characterizing extracellular diffusion properties using diffusion‐weighted MRS of sucrose injected in mouse brain

Mélissa Vincent , Mylène Gaudin , Covadonga Lucas‐torres , Alan Wong , Carole Escartin et al.
NMR in Biomedicine, 2021, 34 (4), pp.e4478. ⟨10.1002/nbm.4478⟩
Journal articles cea-03126700v1
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Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T αsynuclein levels and aggregation

Charlotte Vajhøj , Benjamin Schmid , Ania Alik , Ronald Melki , Karina Fog et al.
PLoS ONE, 2021, 16 (12), pp.e0261536. ⟨10.1371/journal. pone.0261536⟩
Journal articles cea-03500527v1
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Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Hannah Scheiblich , Cira Dansokho , Dilek Mercan , Susanne V. Schmidt , Luc Bousset et al.
Cell, 2021, 184, pp.5089-5106. ⟨10.1016/j.cell.2021.09.007⟩
Journal articles cea-03364079v1
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Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response

Pierre Rosenbaum , Nicolas Tchitchek , Candie Joly , André Rodriguez Pozo , Lev Stimmer et al.
Frontiers in Immunology, 2021, 12, pp.645210. ⟨10.3389/fimmu.2021.645210⟩
Journal articles hal-03321921v1
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Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

Gregory Gauvain , Himanshu Akolkar , Antoine Chaffiol , Fabrice Arcizet , Mina A Khoei et al.
Communications Biology, 2021, 4 (1), pp.125. ⟨10.1038/s42003-020-01594-w⟩
Journal articles hal-03125732v1
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Microglial NLRP3 inflammasome activation upon TLR2 and TLR5 ligation by distinct $\alpha$-synuclein assemblies

Hannah Scheiblich , Luc Bousset , Stephanie Schwartz , Angelika Griep , Eicke Latz et al.
Journal of Immunology, In press, ⟨10.4049/jimmunol.2100035⟩
Journal articles cea-03344484v1
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Validation de nouveaux modèles et traitements de la maladie de Parkinson chez le primate non-humain

Audrey Fayard
Neurosciences. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASL100⟩
Theses tel-03938884v1
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Développement d'outils thérapeutiques ciblant les agrégats d'alpha-synucléine dans les synucléinopathies

Maud Landureau
Biologie moléculaire. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASL022⟩
Theses tel-04010780v1
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Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

Anastasie Maté de Gérando , Marie D’orange , Emma Augustin , Charlène Joséphine , Gwénaelle Aurégan et al.
Brain - A Journal of Neurology , 2021, 12 (4), pp.1167-1182. ⟨10.1093/brain/awab011⟩
Journal articles inserm-03385148v1
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The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Maud Landureau , Virginie Redeker , Tracy Bellande , Stéphanie Eyquem , Ronald Melki et al.
Journal of Biological Chemistry, 2021, 296, pp.100737. ⟨10.1016/j.jbc.2021.100737⟩
Journal articles cea-03219237v1
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Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau

Emilie Caroux , Virginie Redeker , Karine Madiona , Ronald Melki
Journal of Biological Chemistry, 2021, 297, pp.101252. ⟨10.1016/j.jbc.2021.101252⟩
Journal articles cea-03384553v1
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Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

Benedict Tanudjojo , Samiha S. Shaikh , Alexis Fenyi , Luc Bousset , Devika Agarwal et al.
Nature Communications, 2021, 12, pp.3817. ⟨10.1038/s41467-021-23682-z⟩
Journal articles cea-03269839v1
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Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

Suzanne Lam , Fanny Petit , Anne-Sophie Hérard , Susana Boluda , Sabiha Eddarkaoui et al.
Acta Neuropathologica Communications, 2021, 9 (1), pp.165. ⟨10.1186/s40478-021-01266-8⟩
Journal articles inserm-03388548v1
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De nouvelles techniques pour dévoiler le rôle des cellules gliales du cerveau

Anne-Laure Hemonnot-Girard , Lucile Ben Haim , Carole Escartin , Hélène Hirbec
médecine/sciences, 2021, 37 (1), pp.59-67. ⟨10.1051/medsci/2020253⟩
Journal articles hal-03120835v1
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THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

Audrey Vautheny , Charlotte Duwat , Gwennaëlle Aurégan , Charlène Joséphine , Anne-Sophie Hérard et al.
Neurobiology of Disease, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩
Journal articles inserm-03366724v1
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Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

Luis M A Oliveira , Thomas Gasser , Robert Edwards , Markus Zweckstetter , Ronald Melki et al.
npj Parkinson's Disease, 2021, 7, ⟨10.1038/s41531-021-00203-9⟩
Journal articles cea-03308380v1
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Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin , Elena Galea , András Lakatos , James O’callaghan , Gabor Petzold et al.
Nature Neuroscience, 2021, 24, pp.312-325. ⟨10.1038/s41593-020-00783-4⟩
Journal articles hal-03437017v1
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IRM multiparamétrique pour la recherche de biomarqueurs précoces des maladies par expansion de polyglutamine

Jean-Baptiste Pérot
Neurosciences. Université Paris-Saclay, 2021. Français. ⟨NNT : 2021UPASL074⟩
Theses tel-03483657v1
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Zero echo time $^{17}$O-MRI reveals decreased cerebral metabolic rate of oxygen consumption in a murine model of amyloidosis

Celine Baligand , Olivier Barret , Amélie Tourais , Jean-Baptiste Pérot , Didier Thenadey et al.
Metabolites, 2021, 11 (5), pp.263. ⟨10.3390/metabo11050263⟩
Journal articles hal-03447631v1
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Resting state functional atlas and cerebral networks in mouse lemur primates at 11.7 Tesla

Clément M Garin , Nachiket A Nadkarni , Brigitte Landeau , Gaël Chételat , Jean-Luc Picq et al.
NeuroImage, 2021, 226, pp.117589. ⟨10.1016/j.neuroimage.2020.117589⟩
Journal articles hal-03447245v1
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Endogenous levels of alpha-synuclein modulate seeding and aggregation in cultured cells

Eftychia Vasili , Antonio Dominguez-Meijide , Manuel Flores-León , Mohammed Al-Azzani , Angeliki Kanellidi et al.
Molecular Neurobiology, 2021, 59, pp.1273 - 1284. ⟨10.1007/s12035-021-02713-2⟩
Journal articles cea-03683738v1
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Increased microglial activation in patients with Parkinson disease using [$^{18}$F]-DPA714 TSPO PET imaging

Sonia Lavisse , Sébastien Goutal , Catriona Wimberley , Mattéo Tonietto , Michel Bottlaender et al.
Parkinsonism & Related Disorders, 2021, 82, pp.29 - 36. ⟨10.1016/j.parkreldis.2020.11.011⟩
Journal articles hal-03493070v1
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Microglial inclusions and neurofilament light chain release follow neuronal $\alpha$-synuclein lesions in long-term brain slice cultures

Melanie Barth , Mehtap Bacioglu , Niklas Schwarz , Renata Novotny , Janine Brandes et al.
Molecular Neurodegeneration, 2021, 16, pp.54. ⟨10.1186/s13024-021-00471-2⟩
Journal articles cea-03344476v1
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Seeding Propensity and Characteristics of Pathogenic $\alpha$Syn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson’s Disease

Alexis Fenyi , Charles Duyckaerts , Luc Bousset , Heiko Braak , Kelly Del Tredici et al.
Cells, 2021, 10, pp.139. ⟨10.3390/cells10010139⟩
Journal articles cea-03116038v1
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Contribution de la Cellule Covid 19 de l'Académie Vétérinaire de France : Bilan provisoire et perspectives

Marc Dhenain
Bulletin de l'Académie Vétérinaire de France, 2021, 174, ⟨10.3406/bavf.2021.70941⟩
Journal articles hal-03447644v1
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TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Kaspar Russ , Gabriel Teku , Luc Bousset , Virginie Redeker , Sara Piel et al.
Cell Reports, 2021, 34 (12), pp.108895. ⟨10.1016/j.celrep.2021.108895⟩
Journal articles cea-03186002v1
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Pharmacokinetic neuroimaging to study the dose-related brain kinetics and target engagement of buprenorphine in vivo

Sylvain Auvity , Sébastien Goutal , Fabien Caillé , Dominique Vodovar , Alain Pruvost et al.
Neuropsychopharmacology, 2021, 46 (6), pp.1220-1228. ⟨10.1038/s41386-021-00976-w⟩
Journal articles cea-03215261v1