Pré-Publication, Document De Travail Année : 2024

A single theory for the evolution of sex chromosomes and the two rules of speciation

Denis Roze

Résumé

Three major empirical patterns involving sex chromosomes have been observed in higher eukaryotes: Y (or W) chromosomes are often non-recombining and degenerate; when two species hybridize, but one sex is sterile or inviable among hybrid offspring, it is most often the heterogametic sex (XY or ZW)—the so-called Haldane’s rule; and the X (or Z) plays a disproportionately large effect on reproductive isolation compared to autosomes—the so-called large X effect. Each observation has generally received its own tailored explanation involving multiple genetic and evolutionary causes 1–3 . Here, we show that these empirical patterns all emerge from a single theory for sex chromosome evolution incorporating the co-evolution of cis and trans-acting regulators of gene expression, and leading to systematic and rapid misexpression of dosage-compensated genes in the heterogametic F1 hybrids, for young or old sex-chromosomes. This theory offers a level of parsimony and generality rarely seen in biology.
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hal-04736667 , version 1 (24-02-2025)

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Thomas Lenormand, Denis Roze. A single theory for the evolution of sex chromosomes and the two rules of speciation. 2024. ⟨hal-04736667⟩
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